Intact Analysis of Antibody Drug Conjugates
Aplikace | 2018 | SCIEXInstrumentace
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
ZaměřeníKlinická analýza
VýrobceSCIEX
Klíčová slovadar, antibody, reconstructed, adcs, glycosylations, biopharmaview, trastuzumab, drug, mcc, reconstruction, cytotoxic, linker, glycosylated, conjugates, reaction, jacobson, glycoprofile, produces, internalization, exion, linked, intact, which, complexity, lysines, calculate, clearly, pngasef, payloads, liberated, ipm, well, cur, reported, bins, using, deglycosylated, been, conjugation, spectrum, covalently, voltage, has, glycoforms, biologics, complex, ratio, adc, sciex, backbone
Podobná PDF
Glycosylated and Deglycosylated Subunit Analysis of Antibody Drug Conjugates
2017|SCIEX|Aplikace
Glycosylated and Deglycosylated Subunit Analysis of Antibody Drug Conjugates Trastuzumab Emtansine Analysis using Benchtop X500B QTOF Mass Spectrometer Wen Jin, Suya Liu, Doug Simmons, Ian Moore and Sibylle Heidelberger 71 Four Valley Dr. Concord, ON L4K 4V8, Canada Introduction Experimental…
Klíčová slova
biopharmaview, biopharmaviewdeglycosylated, deglycosylatedantibody, antibodychain, chainsubunit, subunitdrug, drugdar, daradcs, adcsmultiplicity, multiplicityconjugated, conjugatedheavy, heavymcc, mccreconstruction, reconstructionlight, lightbone
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC
2016|Agilent Technologies|Aplikace
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…
Klíčová slova
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry
2017|Agilent Technologies|Aplikace
Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents for the treatment of different diseases. This…
Klíčová slova
trastuzumab, trastuzumabadcs, adcsadc, adcemtansine, emtansinedeconvoluted, deconvolutedcounts, countsdrug, drugdeglycosylated, deglycosylatedamu, amumass, masssec, secmabs, mabsbuffer, bufferspectrum, spectrumantibody
Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping
2017|Thermo Fisher Scientific|Aplikace
APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
Klíčová slova
chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactnative, nativesetting, settingmapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylysine