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Use of a Proprietary Polar Column Chemistry for the Separation of Nitrosamines in Sartan and Ranitidine Drug Substances

 

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[ TECHNOLOGY BRIEF ] Reliable HPLC/UV Quantification of Nitrosamine Impurities in Valsartan and Ranitidine Drug Substances Margaret Maziarz and Paul Rainville Waters Corporation, Milford, MA, USA The ACQUITY Arc System with PDA Detector, integrated with an ACQUITY QDa Mass Detector…
Klíčová slova
nitrosamine, nitrosaminevalsartan, valsartanqda, qdaranitidine, ranitidinemin, minloq, loqimpurities, impuritiesndma, ndmaacquity, acquitybrief, briefnmba, nmbaneipa, neipandipa, ndipareliable, reliabledrug
[ TECHNOLOGY BRIEF ] Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Lindsay Hatch, Mary Lame, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA The Xevo TQ-XS Mass Spectrometer,…
Klíčová slova
nitrosamine, nitrosamineranitidine, ranitidinendma, ndmanmba, nmbaneipa, neipandipa, ndipaimpurities, impuritiesndba, ndbandea, ndeadrug, drugquantification, quantificationblank, blanksix, sixnitrosamines, nitrosaminesrecalls
[ TECHNOLOGY BRIEF ] Quick Analysis of N-nitrosodimethylamine (NDMA) in Ranitidine Drug Substance and Drug Product by HPLC/UV Margaret Maziarz and Paul Rainville Waters Corporation, Milford, MA, USA The ACQUITY Arc System with PDA Detector, integrated with an ACQUITY QDa…
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ndma, ndmaranitidine, ranitidinedrug, drugsubstance, substanceqda, qdamin, mintablet, tabletacquity, acquityquick, quickaccurate, accuratebrief, brieftest, testnitrosamine, nitrosaminenitrosodimethylamine, nitrosodimethylamineimpurities
Application Note Development of a Sensitive High Resolution Mass Spectrometry Method for Quantitation of N-Nitrosamines using Tof MRM on the Xevo G2-XS QTof Lauren Mullin, Margaret Maziarz, Mary E. Lame, Nathan Anderson Waters Corporation This is an Application Brief and…
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nitrosamines, nitrosaminessartan, sartannitrosamine, nitrosaminetof, tofunifi, unifiinformatics, informaticsmrm, mrmclass, classhrms, hrmsgastroesophageal, gastroesophagealgxp, gxpstomach, stomachcarcinogenicity, carcinogenicitypusher, pusherplatform
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