COVID-19: Aplikační použití LC, LC/MS a LC/MS/MS systémů 2020 - 2021

COVID-19 (coronavirus disease 2019) je vysoce infekční virové onemocnění, které je způsobeno koronavirem SARS-CoV-2 a více než rok se s ním snažíme bojovat a zvykáme si s ním žít.

Analytická chemie především v podobě výkonných a citlivých LC/MS systému hraje v různých oblastech od kontoly kvality léčiv a vakcín ve farmaceutickém průmyslu, až po klinické aplikace a odhalení přítomosti tohoto viru ve vzorcích pacientů významou roli.

Níže se podíváme na výber nejnovějších aplikací a technických článků.

Klinická analýza (23)

• Comprehending COVID-19: Analytical Science in the Context of COVID-19 | 2020 | Waters; HPLC, LC/MS

• Lessons from COVID-19: Verifying Performance of an HPLC-UV Method with MS-Compatible Conditions for Chloroquine Phosphate Analysis | 2020 | Waters; HPLC, LC/MS, LC-SQ

• Targeted assay for quantification of proteins from the SARSCoV- 2 coronavirus | 2020 | SCIEX; LC/MS, LC/MS/MS, LC/QQQ

• Quantitative Analysis of Favipiravir Spiked in Plasma Using by HPLC | 2020 | Shimadzu; HPLC

• Lessons from COVID-19: Verifying Performance of an HPLC/UV method with MS Compatible Conditions for Hydroxychloroquine Sulfate Analysis | 2020 | Waters; HPLC, LC/MS, LC-SQ

• Lessons from COVID-19: Analysis of Azithromycin using Hydrophilic Interaction Chromatography with LC-MS Compatible Mobile Phases | 2020 | Waters; LC/MS, LC/MS/MS, LC/QQQ

• Simultaneous Analysis of Remdesivir and Metabolites in Human Plasma | 2020 | Shimadzu; LC/MS, LC/MS/MS, LC/QQQ

• Comprehending COVID-19: Reversed-Phase Liquid Chromatography (RPLC) of Intact SARS-CoV-2 Spike Protein | 2020 | Waters; Iontová mobilita, HPLC, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

• Comprehending COVID-19: Rapid and Sensitive Characterization of N-Glycans from SARS-CoV-2 Spike Protein | 2020 | Waters; LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

• Comprehending COVID-19: Fast Analysis of Ribavirin and Related Compounds Using Hydrophilic Interaction Chromatography | 2020 | Waters; HPLC

• Analysis of mRNA Poly-A Sequence Variants by High-Resolution LC/MS | 2021 | Agilent Technologies; LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

• Comprehending COVID-19: Preliminary Examination of the SARS-CoV-2 Spike Protein by Peptide Mapping | 2020 | Waters; LC/TOF, LC/HRMS, LC/MS

• Comprehending COVID-19: Using the Atlantis PREMIER BEH C18 AX Mixed-Mode Column for the Analysis of Umifenovir | 2020 | Waters; Spotřební materiál, HPLC, LC kolony

• Comprehending COVID-19: Maximizing LC-MS Detection Dynamic Range for Multiple Reaction Monitoring Based SARS-CoV-2 Analysis | 2020 | Waters; LC/MS, LC/MS/MS, LC/QQQ

• Comprehending COVID-19: Application of UniSpray and Electrospray Ionization for the Detection of Proteolytic Digested SARS-CoV-2 Proteins | 2020 | Waters; LC/MS, LC/MS/MS, LC/QQQ

• Comprehending COVID-19: LC-MS/MS Analysis of Small Molecule Anti-Viral and Anti-Inflammatory Drugs in Plasma in Clinical Research | 2020 | Waters; LC/MS, LC/MS/MS, LC/QQQ

• Best Practices for Oligonucleotide Analysis Using Ion-Pair Reversed-Phase (IP-RP) Liquid Chromatography – Columns and Chemistries | 2020 | Waters; Spotřební materiál, HPLC, LC kolony

• Comprehending COVID-19: Structural Characterization of the Glycan Assemblies of O-linked Glycopeptides Using Cyclic Ion Mobility | 2021 | Waters; Iontová mobilita, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS

• Method for multiple COVID-19 drugs analysis by LC-MS/MS | 2020 | Shimadzu; LC/MS, LC/MS/MS, LC/QQQ

• Quantitative Analysis of Favipiravir Spiked in Plasma Using by HPLC | 2020 | Shimadzu; HPLC

• Improvements in Sensitivity for Quantification of Steroid Phosphate Drugs Using ACQUITY PREMIER and MaxPeak HPS Columns | 2021 | Waters; LC/MS, LC/MS/MS, LC/QQQ

• Determination of Hydroxychloroquine Concentration in Human Plasma by LC-MS/MS Method | 2020 | Shimadzu; LC/MS, LC/MS/MS, LC/QQQ

• Simultaneous Analysis of Remdesivir and Metabolites in Human plasma Using Fully Automated Sample Preparation LC/MS/MS System | 2020 | Shimadzu; Příprava vzorků, LC/MS, LC/MS/MS, LC/QQQ

Farmaceutická analýza (4)

• JP- and EP-Compliant Analysis of Impurities of COVID-19 Drug Dexamethasone | 2020 | Shimadzu; HPLC

• LCMS™ Bioanalysis of Antibody Drugs Using Fab- Selective Proteolysis nSMOL – Part 7 - Tocilizumab Analysis | 2020 | Shimadzu; LC/MS, LC/MS/MS, LC/QQQ

• Application of HPLC in Quality Analysis of Hydroxychloroquine Sulfate | 2020 | Shimadzu; HPLC

• Oligonucleotide mapping using BioPharma Finder software | 2020 | Thermo Fischer Scientific; LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap