Společnost <a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/companies/37">Altium International s.r.o.</a> je jedním z největších distributorů laboratorního vybavení působící na českém trhu. Zastupuje zde několik významných nadnárodních firem a nabízí zboží z oblasti instrumentace a spotřební materiálu pro chromatografii, hmotnostní spektrometrii, atomovou spektroskopii a molekulovou spektroskopii. Druhou velmi významnou část prodejního portfolia, která v posledních letech zaznamenává významný růst, tvoří produkty z oblasti molekulární biologie, genetiky a buněčné patologie.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HPST_team_2021_e23beef2ba/HPST-team-2021_s.webp" alt="Altium Team v roce 2021" width="493" height="296">Kromě prodeje se zabývá i servisní a školící činností a podporuje svoje zákazníky také řadou dalších služeb, mezi které patří aplikační podpora a vývoj metod pro různé oblasti svého působení. A právě nyní potřebujeme rozšířit tým a hledáme:<h3>OBCHODNÍ REFERENT/KA pro obchod s laboratorními přístroji v oblasti chromatografie, hmotnostní spektrometrie, atomové a molekulové spektroskopie</h3><h4>Co byste u nás dělali?</h4><ul><li>Zajištění komplexního procesu dodávek přístrojů laboratorní techniky zákazníkovi vč. objednávek u dodavatele, zajištění přepravy a instalace u zákazníka, dovozu zboží až po konečnou fakturaci obchodních případů</li><li>Administrativní podporu obchodního týmu</li><li>Telefonická a emailová komunikace s obchodními partnery, koncovými zákazníky a obchodníky a kolegy</li><li>Spolupráce při auditu</li><li>Plnění Ad-hoc úkolů</li></ul><h4>Co bychom pro Vás měli?</h4><ul><li>Stabilní práci, která Vás nebude nudit</li><li>Řešení komplexních obchodních případů</li><li>Funkční ERP systém, který provede celým obchodním procesem</li><li>Krásné pracovní prostředí v nově zrekonstruované vile</li><li>Příjemnou atmosféru v pracovním kolektivu</li><li>Zaškolení</li><li>Výborné platové ohodnocení</li><li>5 týdnů dovolené</li><li>Notebook, mobilní telefon, multisport kartičku, stravenky plně hrazené, penzijní připojištění</li><li>3 dny sickday</li></ul><h4>Co bychom od Vás očekávali?</h4><ul><li>Přirozeně komunikující a samostatnou osobnost se smyslem pro zodpovědnost za výsledek</li><li>SŠ/VŠ/VOŠ vzdělání s orientací na obchod nebo ekonomiku a praxe v obchodní společnosti</li><li>základní znalost zákona o DPH a základní znalost účetních předpisů ČR</li><li>znalost anglického jazyka alespoň na úrovni A2,</li><li>pozitivní myšlení a motivaci k úspěchu</li><li>týmový hráč</li><li>komunikativnost a příjemné vystupování</li><li>zákaznický přístup a ochota pomáhat kolegům s řešením problémů</li><li>preciznost a smysl pro detail</li><li>Ovládání PC (MS Office, internet) znalost Dynamics 365 Business Central výhodou</li></ul><h4>Kdy můžete nastoupit?</h4><ul><li>ideálně ihned</li></ul><blockquote><h4>Kam se obrátit?</h4><ul><li>Barbara Záhorová</li><li>Tel.: 602 179 746</li><li>E-mail: barbara.zahorova@altium.net&nbsp;</li></ul></blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_Team_building_2021_11_e6a62689d1/Altium-Team-building-2021-11.jpg" alt="Altium Team building 2021" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Altium_Team_building_2021_11_e6a62689d1/thumbnail_Altium-Team-building-2021-11.jpg 243w," sizes="100vw" width="4457" height="2859">

OBCHODNÍ REFERENT/KA pro obchod s laboratorními přístroji v oblasti chromatografie, hmotnostní spektrometrie, atomové a molekulové spektroskopie

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s plynovými chromatografy, přinášíme nejnovější literaturu zaměřenou na GC kolony, kterou naleznete v <a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/library?from=2024&amp;instrumentationItems=19-20&amp;manufacturerItems=1&amp;to=2025">knihovně LabRulezGCMS</a>:</h4><ul><li>Optimizing Hydrogen Carrier Gas on GC/MS Using the HydroInert EI Source and 5Q Columns<ul><li>PDF ke stažení <a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/ps_gc_gc_5q_columns_ei_source_asms_2025_mp_358_en_agilent_c5cf1876f0.pdf">ZDE</a></li></ul></li><li>Optimizing the Efficiency and Productivity of GC/MS Workflows to Improve Laboratory Sustainability<ul><li>PDF ke stažení <a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/ps_db_5q_hydroinert_sustainability_asms_2025_mp_365_en_agilent_3cc1d968a1.pdf">ZDE</a></li></ul></li><li>Improved Thermal Stability Leads to Retention Time Stability and Data 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Altium Akce Try and Buy na GC/LC kolony a spotřební materiál

Souhrnný vliv všech složek vzorku – kromě samotného analytu – na odezvu signálu se nazývá matricový efekt. Komponenty matrice, které koeluují s analyt(y), mohou způsobit zesílení nebo potlačení signálu analytu ve srovnání s hodnotou naměřenou u standardního roztoku analytu (tedy bez přítomnosti matrice). Pokud se matricový efekt nevyhodnotí a/nebo nekoriguje, může mít zásadní dopad na přesnost kvantifikace.Pro stanovení matricového efektu lze provést jednoduchý experiment – porovnat odezvu extrahovaného analytu s odezvou neextrahovaného analytu.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Matrix_effect_formula_3b77ff748f.jpg" alt="Phenomenex: Vzorec pro výpočet matricového efektu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Matrix_effect_formula_3b77ff748f.jpg 245w," sizes="100vw" width="1175" height="134">Nejčastějším přístupem, jak se vyhnout nežádoucím matricovým efektům, je odstranění matrice pomocí technik přípravy vzorku (viz Obrázek 1). Tyto techniky mohou být velmi jednoduché – například filtrace vzorku, precipitace proteinů, extrakce z kapaliny do kapaliny, nebo pokročilejší, jako je extrakce na pevné fázi (SPE) či imunoadsorpční zachycení. Matricový efekt lze v některých případech snížit nebo odstranit také optimalizací LC metody, například pomocí gradientů nebo volbou jiné kolony. Příprava vzorku je však často preferována, protože zároveň prodlouží životnost LC kolony.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Figure_1_Common_sample_preparation_approaches_listed_in_order_of_lower_to_higher_selectivity_61e1f39c43.jpg" alt="Phenomenex: Obrázek 1 – Běžné techniky přípravy vzorku seřazené podle rostoucí selektivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Figure_1_Common_sample_preparation_approaches_listed_in_order_of_lower_to_higher_selectivity_61e1f39c43.jpg 220w," sizes="100vw" width="428" height="304">Typickým příkladem matricového efektu je potlačení signálu pozorované při analýze klinických vzorků, jako je krevní plazma nebo sérum, na hmotnostně spektrometrických detektorech. Tyto vzorky obvykle procházejí precipitací proteinů jako nejjednodušším krokem čištění před analýzou. Ten sice pomůže omezit zanášení LC kolony proteiny, ale neodstraní další kontaminanty. Komponenty matrice – zejména fosfolipidy – mohou významně negativně ovlivnit LC analýzy a časem dokonce poškozovat části systému.Na Obrázku 2 je porovnán interferující signál pocházející z fosfolipidů u: (A) séra po pouhé precipitaci proteinů a (B) séra dále vyčištěného extrakcí na pevné fázi pomocí sorbentu Strata™-X PRO.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Figure_2_Phospholipid_traces_obtained_from_human_serum_samples_after_protein_precipitation_7e049e93c4.jpg" alt="Phenomenex: Obrázek 2 – Chromatografy stop fosfolipidů v lidském séru po precipitaci proteinů." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Figure_2_Phospholipid_traces_obtained_from_human_serum_samples_after_protein_precipitation_7e049e93c4.jpg 245w," sizes="100vw" width="677" height="386">Po vyčištění pomocí Strata-X PRO byla pozorována desetinásobná redukce interferujícího signálu z fosfolipidů. Tento polymerní sorbent byl speciálně navržen pro pokročilé odstranění matrice a – jak je vidět výše – účinně odstraňuje fosfolipidy i škodlivé částice ze vzorku, čímž zlepšuje výtěžnost analytů i reprodukovatelnost.Doufáme, že pro vás byl tento tip užitečný! Prohlédněte si náš nástroj a produkty níže.<h4>Strata-X PRO SPE produkty</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/products/strata-x-pro-solid-phase-extraction-products">Phenomenex: Strata-X PRO SPE</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Strata_X_PRO_SPE_Products_7d659c74c2.jpg" alt="Phenomenex: Strata-X PRO SPE" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Strata_X_PRO_SPE_Products_7d659c74c2.jpg 239w," sizes="100vw" width="387" height="253"><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/tools/spe-method-development">SPE Method Development Tool</a></li></ul>

Tip pro přípravu vzorků – Co je to matricový efekt?

Akademie

Kariéra

Článek

Produkt

Video

Je autorizovaným distributorem společnosti Agilent Technologies pro Českou republiku v oblastech chromatografie (GC, HPLC, UHPLC, kapilární elektroforéza) a hmotnostní spektrometrie (GC/MS, LC/MS, CE/MS), disolučních aparátů, molekulární (UV-Vis, UV-Vis-NIR, fluorescence, FTIR analyzátory a mikroskopy) a atomové spektroskopie (ICP-OES, ICP-MS, AAS), a v neposlední řadě také v oblasti molekulární biologie a genomiky (analýza nukleových kyselin a proteinů, microarray skenery a skla, PCR & RT-PCR, qPCR, řešení pro NGS, reagencie pro mutagenezi a klonování, sondy FISH a další).

Altium International

Společnost Phenomenex je celosvětovým technologickým lídrem, který se zabývá vývojem nových řešení v oblasti analytické chemie, jež řeší požadavky analytiků na separace a purifikace v průmyslových, vládních a akademických laboratořích.

Phenomenex

Agilent Technologies

Thermo Fisher Scientific

C&EN

Shimadzu Corporation

Evosep Biosystems

Waters Corporation

Discover even more analysis you can perform with the Cary 60 UV-Vis in the Environmental area.
<blockquote>
Presenter: Luciana Terra (Application Scientist, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Luciana Terra has a Bachelor’s degree in Industrial Chemistry from the Federal University of Alfenas (Unifal-MG) as well as a Ph.D. in Analytical Chemistry, on Chemometrics, from the State University of Campinas (Unicamp), where she developed work focused on petroleum quality and derivatives using high-resolution Mass Spectrometry, NIR, and chemometrics methodologies. As part of her Ph.D., she also worked at the University of Calgary in Canada. While completing her Master’s Degree at Unicamp, Luciana developed a new methodology for drug polymorphism detection using NIR imaging and chemometrics tools for quality assurance in the pharmaceutical industry. In 2019, she joined Agilent Technologies as an Application Scientist for Molecular Spectroscopy in UV-Vis, Fluorescence, IR, and Raman techniques, at Agilent Technologies, in Brazil.
</blockquote>

Analysis of aqueous Environmental samples using UV-Vis instrumentation

Discover even more analysis you can perform with the Cary 60 UV-Vis in the Environmental area.

Analysis of aqueous Environmental samples using UV-Vis

<div><h4>FFF Master Class: Master the Hardware Behind Field-Flow Fractionation</h4>Understand the inner workings and troubleshoot unexpected effects in FFF systems.A deep dive into FFF hardware, this master class is perfect for lab professionals facing challenges in field-flow fractionation.<h5>Friday, December 12: Understanding FFF hardware</h5><ul><li>Have you seen unexpected effects?</li><li>Where does the flow go?</li><li>Why do I need pressure?</li></ul><h4>Why Attend:</h4><ul><li>Deepen your understanding of FFF.</li><li>Gain actionable insights for your lab.</li><li>Interact with our expert, Dr. Andy Meyer.</li></ul><blockquote>Presenter: Dr. Andy MeyerDr. Andy Meyer joined Wyatt Technology in 2001, serving for several years as an Applications Scientist, then as Dean of Wyatt's "Light Scattering University" and as Director of Customer Service &amp; Support. After managing multiple regions in North America, Dr. Meyer is now a Senior Application Scientist for Wyatt. As a Wyatt customer, he completed his Ph.D. in Applied Science – Polymer Chemistry from the College of William and Mary in Virginia.</blockquote></div>

Waters Corporation: FFF Master Class: Master the Hardware Behind Field-Flow Fractionation

FFF Master Class: Master the Hardware Behind Field-Flow Fractionation

Join Dr. Andy Meyer on Dec 5 for a deep dive into FFF hardware. Learn to troubleshoot flow issues, pressure effects, and optimize system performance.

Master the Hardware Behind Field-Flow Fractionation

The holiday season often means extra downtime for overworked scientists. Infrequent use or improper shutdown for your HPLC instrument can lead to blockages, biological growth, and decreased performance. Before you head out for the holidays, there are proactive steps you should consider for maintaining and servicing your HPLC. In this webinar we will cover how to properly shut down your instrumentation, so that it is ready to run as soon as the lab starts up again. We will also cover how to restart and what to do if your instrument was improperly stored. While the focus will be on Agilent equipment, we will cover many best practices across the analytical industry. With proper care, both you and your HPLC can return to work refreshed and ready for action.<blockquote>Presenter:&nbsp; Melissa Goodlad (Application Engineer, Agilent Technologies, Inc.)Melissa Goodlad is an Application Engineer providing applications assistance and technical support for Agilent’s HPLC columns and consumables. Before joining Agilent, Melissa was completing her PhD in Physical Chemistry at UC Merced studying nanoparticle self-assemblies.</blockquote>

Agilent Technologies: HPLC Holiday Special: Proper Downtime Maintenance for Your Instrument

HPLC Holiday Special: Proper Downtime Maintenance for Your Instrument

In this webinar we will cover how to properly shut down your instrumentation, so that it is ready to run as soon as the lab starts up again.

Proper Downtime Maintenance for HPLC Instrument

Join us for an exciting seminar dedicated to the latest innovations and techniques in the biopharma industry. This event will showcase cutting-edge workflows in proteomics and structural biology, highlighting how these advancements are transforming biopharmaceutical research and development.<h4>Why Attend?</h4><ul><li>Explore customer workflows: Discover how leading companies are implementing innovative workflows to drive efficiency and effectiveness in their research and development processes.</li><li>Discover new product innovations: Learn about the latest products that are revolutionizing the biopharmaceutical industry.</li><li>Network with industry leaders: Meet with experts and peers to gain valuable insights and stay at the forefront of biopharmaceutical innovations.</li></ul><h4>Topics Covered:</h4><ul><li>Proteomics: Dive into the latest techniques and advancements in proteomics.</li><li>Structural Biology: Explore the cutting-edge developments in structural biology.</li><li>and more</li></ul><h4>Preliminary Agenda:</h4><h5>10:00 Welcome coffee registration</h5><h5>Single cell and immunopeptidomics explorations on Orbitrap-Astral&nbsp;</h5><ul><li>Farida Salimova and Jeewan Babu Rijal, LSMBO</li></ul><h5>Mastering Single Cell Proteomics: Daily Excellence with μPAC Neo Plus Trap-and-Elute Workflow&nbsp;</h5><ul><li>Jeff Op de Beeck, R&amp;D Staff Scientist, Thermo Fisher Scientific</li></ul><h5>Host Cell Protein on the Thermo Scientific Orbitrap Astral&nbsp;</h5><ul><li>Severine Clavier, Sanofi</li></ul><h5>12:00 Lunch break</h5><h5>13:30 Driving the process development of recombinant therapeutic products with automated mass spectrometry-based target peptide mapping&nbsp;</h5><ul><li>Diego Bertaccini, Merck</li></ul><h5>15:00 Coffee break &amp; networking opportunities (End of the event around 15:30)</h5><h4>Who Should Attend?</h4><ul><li>Biopharmaceutical researchers and scientists</li><li>Industry professionals and leaders</li><li>Anyone interested in the latest biopharma innovations</li></ul>Participation is free of charge. A registration is required.&nbsp; The event language is English.Don't miss out on this opportunity to enhance your knowledge and network with industry leaders. Register now to secure your space!For more information about the event or for questions regarding your registration, please contact analyze.eu@thermofisher.com.We look forward to seeing you at the seminar!<blockquote>Presenter: Information about speakers will be published soon</blockquote>

Thermo Fisher Scientific: Omics innovations for the biopharmaceutical industry

Omics innovations for the biopharmaceutical industry

Join us for an exciting seminar dedicated to the latest innovations and techniques in the biopharma industry.

<div>Join us for an informative session with Clint Riach, Product Manager for Hamilton Lab Solutions, as we explore the Microlab® Prep™ automated liquid handling system. This webinar is tailored for bench scientists seeking to streamline workflows and boost research efficiency with a compact, bench-friendly system featuring intuitive graphical software and robust, reliable performance.Discover how the Microlab Prep frees you from repetitive manual pipetting tasks, giving you more hands-off time to focus on research design and data analysis.<h4>What to Expect:</h4><ul><li>Comprehensive System Overview: Gain insights into the Microlab Prep hardware and software, designed to simplify your laboratory processes and enhance daily workflows.</li><li>Step-by-Step Protocol Setup: Watch a live demonstration of setting up a simple PCR preparation protocol, showcasing the ease of implementing automated liquid handling using our intuitive graphical software.</li><li>Latest Features Highlighted:<ul><li>Prep CAP HEPA/UV Contamination Control: Ensure accurate and reliable results.</li><li>CO-RE II Pipetting Technology: Enhance precision in liquid handling while reducing errors.</li></ul></li><li>Q&amp;A Session: Insights from Hamilton’s product manager and automation expert, Clint Riach</li></ul><blockquote>Presenter: Clint Riach, Product Manager for Hamilton Lab Solutions</blockquote></div>

C&EN: Automated Liquid Handling for Bench Scientists: Meet Hamilton’s Most Compact Workstation

Automated Liquid Handling for Bench Scientists: Meet Hamilton’s Most Compact Workstation

Discover how the Microlab Prep frees you from repetitive manual pipetting tasks, giving you more hands-off time to focus on research design and data analysis.

Automated Liquid Handling for Bench Scientists

Mass spectrometry (MS)-based proteomic biomarker discovery pipeline commonly begins with large-scale profiling techniques detecting thousands of candidate biomarkers. Efficiently triaging these biomarker candidates for advancement to the biomarker verification stage of the biomarker development pipeline is not trivial. Historically, immunoassays have been used as the method of choice for targeted protein quantification. However, these antibody-based methods include several limitations, including cross-reactivity due to poor specificity and selectivity, which limits the multiplexing abilities of these assays.Targeted MS methods such as parallel reaction monitoring (PRM) can overcome these limitations by identifying and quantifying peptides and proteins in complex biological samples with high accuracy, sensitivity, and reproducibility. A recent advancement in PRM is its application on a novel mass spectrometry platform, the Thermo Scientific™ Stellar™ mass spectrometer which features a dual-pressure linear ion trap mass analyzer. The Stellar MS has significantly enhanced PRM capabilities facilitating quantitative targeted MS analyses that require high measurement precision and accuracy, low limits of detection/quantification, ruggedness, and throughput. In this webinar, Dr. Thomas will provide a glimpse into how PRM on the Stellar MS can be used as a high-throughput targeted MS approach to identify and prioritize novel predictive proteomic biomarkers of drug resistance in ovarian cancer.<h5>Learning Objectives:</h5><ul><li>Learn how mass spectrometry can be applied during the verification stage of biomarker development</li><li>Understand the enhanced PRM capabilities of the Stellar MS in supporting targeted mass spectrometry applications</li><li>Learn key concepts from consensus guidelines regarding the use of targeted MS for peptide and protein quantification</li></ul><blockquote>Presenter: Stefani Thomas, PhD, University of Minnesota, Assistant ProfessorStefani earned her BA in Biological Sciences with a Minor in Music from Dartmouth College and her PhD in Pharmaceutical Sciences from the University of Southern California. After completing a research postdoctoral fellowship in the lab of Dr. Robert Cotter at Johns Hopkins, Stefani joined the Center for Biomarker Discovery and Translation at Johns Hopkins where she was a member of the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC). She then completed a Clinical Chemistry postdoctoral fellowship at Johns Hopkins and earned board certification from the National Registry of Certified Chemists and the American Board of Clinical Chemistry. Currently, Stefani is an Assistant Professor in the Department of Laboratory Medicine and Pathology at the University of Minnesota, she is the Associate Medical Director of the M Health Fairview West Bank Laboratory, and she has authored more than 70 publications. Her research laboratory applies mass spectrometry-based clinical proteomics to elucidate the biology of ovarian cancer towards improved patient stratification for therapeutic treatment.&nbsp;</blockquote>

Thermo Fisher Scientific: Breaking Barriers: Practical Approaches to Translating Proteins from Biomarker Candidates to Verified Biomarkers

Breaking Barriers: Practical Approaches to Translating Proteins from Biomarker Candidates to Verified Biomarkers

Learn how Stellar MS enhances PRM for targeted proteomics, enabling precise biomarker verification and helping identify predictive markers of drug resistance.

Approaches to Translating Proteins from Biomarker Candidates

Unlock the full potential of plasma proteomics with robust LC-MS workflows powered by Evosep. Discover how standardized, Evotip-based methods deliver exceptional depth, reproducibility, and scalability – ideal for large-cohort studies and population-level disease monitoring.<h5>BENCHMARK OF ENRICHMENT AND DEPLETION METHODS FOR QUANTITATIVE PLASMA PROTEOMICS AND THEIR CORRELATION TO CLINICAL ROUTINE MEASUREMENT.</h5><ul><li>Talk by Anders H. Kverneland, PhD., MD at Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital</li></ul>In recent years several preparatory techniques for enrichment or depletion for MS proteomics have been developed to overcome the extreme dynamic range in plasma. In this study we test and benchmark several workflows with intra- and inter-sample comparisons. In addition we test the correlaton to clinical routine protein analyte measurements performed at the hospital laboratory.

Evosep Biosystems: Plasma Proteomics in translational medicine

Plasma Proteomics in translational medicine

Unlock the full potential of plasma proteomics with robust LC-MS workflows powered by Evosep. 

<div>The Waters Xevo CDMS delivers game-changing improvements in the measurement and characterization of high mass and highly heterogeneous compounds, paving the way for breakthroughs in fields such as gene therapy and structural biophysics.Join us for this webinar to explore how the Waters Xevo CDMS is revolutionizing the analysis of complex biomolecules.Learn how cutting-edge innovations are transforming research-grade technology into accessible, high-performance tools - enabling simplified, compliant workflows and deeper insights into rAAVs, VLPs, mRNA/LNPs, and more.<ul><li>Gain insights on Waters Xevo CDMS product, from the nanoESI emitter, to ELIT. Learn the development journey of the research grade CDMS technology from Indiana University into a commercial product that enables the democratization of the novel technology.</li><li>Learn application space of the Waters Xevo CDMS, hearing application examples based on collaboration with Key Opinion Leaders from the Pharma and Biotech industry and from various research institutes.</li><li>Hear from Pfizer scientist to examine how ELIT CDMS has evolved through commercialization, address key considerations for introducing Xevo CDMS into an industrial setting and highlight user experiences across multiple modalities with Xevo CDMS.</li></ul><blockquote>Presenter: Lauren Barnes, Ph.D. (Senior Scientist, Pfizer)Dr. Lauren Barnes is a Senior Scientist at Pfizer within the Biotherapeutics and Pharmaceutical Sciences division at Pfizer. She joined Pfizer September 2022 as a mass spectrometrist within the Analytical Research &amp; Development (ARD) organization performing heightened characterization on biotherapeutic molecules, including proteins and gene therapies. In this role, she has expanded her expertise to include mass photometry, leveraging her background in the analysis of large, intact biomolecular species to develop methods for species characterization with this emerging technique. Lauren has contributed to collaborative efforts involving CDMS, both during her graduate research and in her professional role at Pfizer.Lauren received her Ph.D. in Analytical Chemistry from Indiana University Bloomington in 2022. Her graduate research focused on the analysis of intact viral gene therapy systems using charge detection mass spectrometry (CDMS) in the lab of Dr. Martin Jarrold.Presenter: Jakub Ujma, Ph.D. (Principal Consulting Technical Product Lead, Waters Corporation)Jakub works at Waters Corporation as a Principal Consulting Technical Product Lead in mass spectrometry R&amp;D. His work has focused on Charge Detection Mass Spectrometry (CDMS), with applications in the analysis of large biomolecules such as protein complexes and virus particles. Jakub leads the development of the Waters Xevo™ CDMS system, which utilizes an electrostatic linear ion trap to enable unambiguous mass measurement of megadalton-sized molecules. In addition to CDMS, Jakub also contributed to a number of projects involving ion mobility and time-of-flight (ToF) mass spectrometry, such as hardware design and performance characterization. He has co-authored several research papers and regularly participates in scientific meetings and discussions within the mass spectrometry community.Jakub received his PhD in Chemistry from Manchester University with a focus on ion mobility techniques for studying protein structure.Presenter: Anisha Haris, Ph.D. (Senior Applications Scientist, Waters Corporation)Anisha is a Senior Applications Scientist in the Charge Detection Mass Spectrometry (CDMS) Program at Waters Corporation. Her work focuses on supporting the evaluation, development, and commercialization of charge detection mass spectrometry (CDMS) for the precise characterization of large, complex, and heterogeneous biomolecules - including protein complexes, virus-like particles, and viral vectors. By bridging cutting-edge instrumentation with real-world applications, Anisha supports the expansion of CDMS through close collaboration with researchers and industry partners in biopharmaceutical development, structural biology, and virology.Anisha received her Ph.D. from the University of Warwick. Her dissertation was focused on “Advanced Applications of Mass Spectrometry for Isomer Differentiation and Analysis of Biomolecules”.</blockquote></div>

Waters Corporation: Unveiling the Waters Xevo CDMS: Biomolecule Characterization Redefined

Unveiling the Waters Xevo CDMS: Biomolecule Characterization Redefined

Join us for this webinar to explore how the Waters Xevo CDMS is revolutionizing the analysis of complex biomolecules.

Waters Xevo CDMS Biomolecule Characterization

Supercritical fluid chromatography (SFC) is gaining renewed attention for its sustainable, cost-effective, and highly sensitive capabilities—offering the potential to outperform traditional HPLC and GC methods.In this latest session of Digital Classrooms, join our experts, Derrick Tan and Chua Chee Keong, as they explore the principles and diverse applications of supercritical fluid extraction (SFE) and SFC, with a focus on achieving precise and efficient separations. Experience the innovation of Shimadzu’s Nexera UC SFE/SFC system, which redefines performance standards with fully automated on-line extraction and separation, along with an eco-friendly performance that reduces solvent usage by 94.2% compared to normal-phase methods.Complementing the leading-edge system is our extensive lineup of chiral and achiral SFC columns, including the newly released ShimOMNIA column, designed for exceptional enantioselectivity and robust performance. Additionally, our collaboration with Core Separations enables seamless scalability, taking your workflow from research to industrial-scale production. This partnership delivers a fully integrated, end-to-end solution to meet all your separation needs.Don’t miss this opportunity to elevate your expertise—Register today and secure your spot!<h4>Learning Objectives:</h4><ul><li>Gain insights on the use of Nexera UC system for analytical to preparative SFC separation.</li><li>Explore the wide range of Shimadzu SFC columns for optimum achiral and chiral separation.</li><li>Discover the capabilities of small to industrial scale SFE from Core Separation.</li></ul><blockquote>Presenter: Derrick Tan (Senior Application Chemist, Shimadzu (Asia Pacific) Pte Ltd)Derrick obtained his PhD in Chemistry from Nanyang Technological University, Singapore. With over 7 years of extensive research experience, Dr Derrick has specialized in various areas, including small molecules, nucleic acids, peptides, and protein synthesis, as well as separation and purification techniques. He joined Shimadzu (Asia Pacific) Pte Ltd in 2021 as an Application Chemist (Consumables). In this role, he is responsible for providing technical support and application expertise for consumables in chromatography and spectroscopy. Portfolio under his care includes a wide range of products, such as LC and GC columns, UV/Vis cuvettes, sample preparation products, sample vials, and other accessories.Presenter: Chua Chee Keong (Product Specialist (LC), Shimadzu (Asia Pacific) Pte Ltd)Chee Keong is the LC/SFC Product Specialist at Shimadzu Asia Pacific with more than five years of experience in analytical science. He specializes in providing technical consultation to researchers and laboratory professionals, helping them optimize methodologies and achieve precise results. Prior to joining Shimadzu, he gained valuable experience across diverse industries, including oil and gas, pharmaceuticals, and life sciences. His expertise spans from laboratory operations and analytical methodologies, with a strong focus on active pharmaceutical ingredient (API) analysis, formulation development, and method transfer to manufacturing, ensuring seamless scalability and precision in production. Chee Keong holds a bachelor’s degree in Analytical Chemistry from Universiti Sains Malaysia, (USM).</blockquote>

Shimadzu: Advancing Separation Science: SFE/SFC For Chiral & Achiral Analysis

Advancing Separation Science: SFE/SFC For Chiral & Achiral Analysis

Discover SFE/SFC principles, Nexera UC automation, and Shimadzu column options for precise, scalable, and eco-friendly separations. Register for this session.

SFE/SFC For Chiral & Achiral Analysis

<div>We are delighted to invite you to the Effective GLP-1 Drug Development Summit, a focused session bringing together leading experts to discuss innovative strategies and analytical solutions for GLP-1 drug development. &nbsp;This event will cover all aspects of drug development.<h4>HIGHLIGHTS</h4><h5>Advancing GLP-1 Therapeutics—A Scientific Imperative to Address Early Development and Manufacturing Challenges</h5>The therapeutic renaissance of GLP-1 receptor agonists has catalyzed a paradigm shift in the treatment of metabolic disorders. Originally developed for glycemic control in type 2 diabetes, GLP-1 analogs now demonstrate robust efficacy in obesity, cardiovascular risk reduction, and in other treatments. With the next frontier of these blockbuster therapeutics well on its way to approval, the GLP-1 field is only going to grow, with novel combinations, indications, and formulations being explored.<h5>Scientific Complexity in Early Development</h5>The pharmacological success of GLP-1 is underpinned by their pleiotropic effects on insulin secretion, appetite regulation, and gastric emptying. Yet, translating these mechanisms into next-generation therapies—such as dual and triple incretin agonists—requires a nuanced understanding of receptor dynamics, biased agonism, and tissue-specific signaling. &nbsp;As peptides become more popular in the development of new therapeutics, it is increasingly important to quickly optimize the synthetic and cleavage processes by isolating and identifying both the target peptide and its related impurities.<h5>Manufacturing: A Peptide-Specific Bottleneck</h5>From a bioprocessing perspective, GLP-1 analogs present unique challenges due to their peptide nature:<ul><li>Peptide Stability: GLP-1 analogs are prone to degradation due to their sensitivity to temperate, pH and enzymatic activity.</li><li>Purity requirement: High purity is essential for therapeutics peptides, as impurities can affect efficacy and safety.</li><li>Complex synthesis: Involves solid-phase peptide synthesis, which can lead to incomplete couplings, deletion sequences and side reaction, requiring optimization.</li><li>Scalability: Transition from small-scale synthesis to large scale manufacturing while maintaining consistency and quality is challenging</li></ul><h4>AGENDA</h4><ul><li>Accelerating Method Development and QC with LC-UV-MS for GLP-1 Agonists<ul><li>Steve Calciano &nbsp;</li></ul></li><li>Characterisation of GLP-1 Peptides and Impurities using HRMS and Ion Mobility&nbsp;<ul><li>Jon Fox &nbsp;</li></ul></li><li>Light Scattering solutions to analyse oligomeric state and aggregation in GLP-1 formulations&nbsp;<ul><li>Sophia Kenrick &nbsp;</li></ul></li><li>Bio-Analytical Quantification of GLP-1 Peptides: A Case Study on Semaglutide&nbsp;<ul><li>Henry Foddy &nbsp;</li></ul></li><li>Panel Discussion with All Speakers &nbsp;</li></ul><h4>Why Attend?</h4>Gain insights into cutting-edge analytical techniques, practical case studies, and collaborative discussions to advance GLP-1<blockquote>Presenter: Antonia Wierzbicki (Principal MS Market Dev Manager, EMEA, Waters Corporation)Antonia Wierzbicki is a MS market development manager at Waters working in EMEA. Antonia has BSc in Pharmaceutical Science and a MSc in Cancer Pharmacology.Following several years working as an analytical chemist in drug development roles within both academic labs and contract research organizations, Antonia has more recently spent time working with analytical chemists to provide solutions using cutting edge technologies to meet their needs and requirements, with a specific interest in ultra-sensitive quantitation of small molecules.Antonia is based in Cambridge UK and keen to connectwith like-minded scientists in the field.Presenter: Sophia Kenrick, Ph.D. (Director of Analytical Sciences, Waters | Wyatt Technology)Sophia received her Ph.D. in Chemical Engineering from the University of California, Santa Barbara, USA, where she utilized a variety of biophysical techniques, including surface plasmon resonance and quantitative flow cytometry, for characterizing combinatorial protein-binding ligands.Sophia joined Wyatt in 2010 and has provided support to the Sales and Marketing teams and R&amp;D product development efforts. She supports multiple applications for Wyatt instrumentation, especially in the field of molecular recognition and biomolecular interactions.Presenter: Henry Foddy (Associate Scientist, Waters Corporation)Henry is a Scientist in the Routine Mass Detection Team at Waters, working on applications to support Waters’ single quadrupole portfolio that span a variety of market segments. He has almost 3 years of experience with Waters, working previously in a food and environmental role support regulatory testing of Pesticides, PFAS, and Pyrrolizidine Alkaloids. Prior to joining Waters, Henry obtained an MSc in Neuroscience from King’s College London.Presenter: Steven Calciano (Senior Product Manager, Waters Corporation​)Steven Calciano joined Waters Corporation in 2015 and is responsible bringing innovative large molecule chromatography and mass spectrometry sample preparationsolutions to market. Prior to his current role, Steven supported analytical standards andreagents products across pharmaceutical, environmental, chemical and food industries,gaining an understanding of a variety of complex analytical workflows. He strives to bringenabling technology to LC-MS users which simplify complex sample preparation methods.​Presenter: Jonathan Fox (Principal Applications Chemist, Waters Corporation)Jonathan Fox is a Consulting Scientist within the Process Analytics Applications team at Waters, based in Wilmslow, UK. With extensive expertise in analytical science, Jonathan plays a pivotal role in advancing solutions that enable customers to achieve greater efficiency and precision in their workflows particularly for complex new modalities.In his current role, Jonathan collaborates closely with cross-functional teams to develop and implement innovative analytical strategies for biological therapeutics. His work focuses on integrating cutting-edge instrumentation and software to support robust, data-driven decision-making in regulated environments.Jonathan is a trusted technical advisor, and a key contributor to developing and demonstrating advanced analytical workflows. His deep understanding of characterising and identifying complex molecules such as oligonucleotides, peptides and therapeutic proteins; using advanced analytical instrumentation; and commitment to scientific excellence make him a valuable resource and partner for complex analytical workflows.</blockquote></div>

Waters Corporation: Effective GLP-1 Drug Development Online Summit

Effective GLP-1 Drug Development Online Summit

Discover key analytical and manufacturing insights for GLP-1 drug development, including LC-MS, HRMS, light scattering, and bioanalytical case studies.

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