<div><div>Vědci z Ústavu organické chemie a biochemie AV ČR (ÚOCHB) vyvinuli průlomovou technologii pro efektivní vývoj aptamerů. Nová metoda propojuje několik biochemických a bioinformatických kroků a otevírá cestu k novým diagnostickým a terapeutickým aplikacím. Mezi ně patří například nositelné senzory schopné v reálném čase sledovat hladiny vybraných biomarkerů v těle a včas upozornit na blížící se zdravotní komplikace. Výsledky zveřejnil časopis Nature Communications.</div></div><div>Aptamery jsou krátké řetězce DNA nebo RNA, které dokážou velmi přesně rozeznat a navázat konkrétní cílovou molekulu. Podobně jako protilátky je lze využít k detekci nebo ovlivnění funkce těchto molekul. Na rozdíl od protilátek jsou však mnohem stabilnější, lze je vyrábět synteticky a přesně chemicky upravovat podle požadovaných vlastností. Díky tomu mohou získat vlastnosti, kterých nelze u protilátek dosáhnout.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg" alt="ÚOCHB: Nová technologie inovuje vývoj aptamerů, syntetických alternativ protilátek: Chemicky upravený DNA aptamer navázaný na cílový protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_2_81e99b9900.jpg 228w," sizes="100vw" width="1343" height="916">S rostoucí poptávkou po přesných a rychlých diagnostických nástrojích jsou aptamery v mnoha případech vhodnější než samotné protilátky. Jejich vývojový proces je však experimentálně a časově náročný a vyžaduje experty z několika vědních oborů. Tým vědců z ÚOCHB vedený dr. Markem Ondrušem a <a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/">prof. Michalem Hockem</a> nyní vyvinul technologii, která celý vývojový proces výrazně zkracuje.„Vývoj aptameru často připomíná hledání jehly v kupce sena. Ve směsi bilionů různých DNA sekvencí se snažíme najít jedinou, která se silně a specificky váže na cílovou molekulu. Náš nový přístup umožňuje nejdřív nalézt ‚aptamerové rodiny‘ – stovky sekvencí s jistou podobností a následně identifikovat člena rodiny, který vykazuje nejlepší experimentální vlastnosti. Tento prvek přispívá ke zkrácení vývoje z několika měsíců na dny,“ říká Marek Ondruš.<blockquote>Video: <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=-aoGvOKqORo">Nová technologie inovuje vývoj aptamerů, syntetických alternativ protilátek&nbsp;</a></blockquote>Výzkumníci zároveň rozšířili možnosti využití aptamerů. Jejich stavební bloky totiž chemicky upravují – připojují k nim nové funkční skupiny, které můžeme přirozeně najít například v aminokyselinách. Takto vzniklé molekuly kombinují výhody DNA i protilátek: pořadí jednotlivých stavebních bloků je dané pořadím písmen v DNA a díky rozmanitosti připojených chemických modifikací se výrazně rozšiřují možnosti aptameru rozpoznávat biologicky významné cíle a napodobovat interakce typické pro proteiny, které jsou základem mnoha biologických procesů.&nbsp;Potenciál nové metody ukázali vědci na lidském inzulinovém receptoru, klíčovém proteinu zapojeném do regulace hladiny cukru v krvi. Vyvinuli aptamer, který se na receptor specificky váže, a pomocí kryoelektronové mikroskopie detailně popsali molekulární mechanismus vzájemné vazby.„Ukázali jsme, že chemicky zavedené funkční skupiny mají zásadní význam nejen pro rozpoznání a vytvoření komplexu aptameru s proteinem, ale také pro stabilizaci samotné struktury DNA aptameru. Naše výsledky poskytují nový pohled na to, jak lze pomocí chemicky upravených nukleových kyselin napodobovat vlastnosti proteinů,“ shrnuje Marek Ondruš.Technologie by v budoucnu mohla doplnit nebo v některých aplikacích dokonce nahradit diagnostické nástroje založené na protilátkách. Výzkumníci spolupracují na dalším rozvoji technologie se společností <a target="_blank" rel="noopener noreferrer" href="http://iocbtech.cz/">IOCB Tech</a>, která pomáhá přetavit objevy z ÚOCHB do praxe.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg" alt="ÚOCHB/Tomáš Belloň: Nová technologie inovuje vývoj aptamerů, syntetických alternativ protilátek: Dr. Marek Ondruš, první autor studie, a prof. Michal Hocek, vedoucí vědecké skupiny Bioorganická a medicinální chemie nukleových kyselin, ÚOCHB" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nova_technologie_inovuje_vyvoj_aptameru_syntetickych_alternativ_protilatek_9694c21671.jpg 234w," sizes="100vw" width="2000" height="1335"><blockquote><h4>Původní článek</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-73676-y">Expedient single-round selection of hyper-modified aptamer targeting insulin receptor from over-represented dually nucleobase-modified DNA libraries</a></h4>Pablo Alberto Franco-Urquijo, Marek Ondruš, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharová, Lucie Mužíková Čechová, Hana Šváchová, Alena Semerádtová, Anatolij Filimoněnko, Adéla Fejfarová, Jiří Homola, Tomáš Kouba &amp; Michal HocekNat. Commun., 2026<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41467-026-73676-y">https://doi.org/10.1038/s41467-026-73676-y</a>&nbsp;<h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstrakt</h4>Objev funkčních nukleových kyselin z knihoven náhodných sekvencí se obvykle opírá o několik časově náročných iterativních kol in vitro selekce s nízkou mírou úspěšnosti. V této práci představujeme strategii selekce v jediném kole, která umožňuje rychlý screening několika nadreprezentovaných DNA knihoven s modifikovanými nukleobázemi a různých selekčních podmínek a dokáže identifikovat modifikované aptamery s vysokou afinitou. Dvojitá separace následovaná amplifikací eluovaných sekvencí, analýzou NGS a klastrováním umožňuje rychlou identifikaci kandidátních aptamerů. Screening modifikovaných DNA knihoven obsahujících modifikované adeninové a uracilové nukleotidy nesoucí hydrofobní aromatické fenylové a indolové skupiny vedl k vývoji aptameru, který se váže na lidský inzulinový receptor se subnanomolární afinitou a mimořádnou specificitou. Struktura stanovená kryoelektronovou mikroskopií odhaluje význam každé aromatické modifikace, a to buď při stabilizaci sekundární struktury, nebo při zprostředkování interakcí s povrchem proteinu. Tento přístup překonává hlavní omezení selekce aptamerů a má potenciál pro vysokokapacitní screening i urychlení vývoje aptamerů nové generace pro diagnostické nebo terapeutické aplikace.</div>

Nová technologie inovuje vývoj aptamerů, syntetických alternativ protilátek

<div><div>Nadace Experientia podpoří tříletým start-up grantem vycházející hvězdu organické chemie Petru Vojáčkovou. Mladí talentovaní vědci Tereza Edlová a Ladislav Prener vycestují na zahraniční stáže.</div></div><div><div><a target="_blank" rel="noopener noreferrer" href="https://www.experientia.cz/start-up-granty/vyvijime-nove-strategie-pro-stavbu-molekul">Petra Vojáčková </a>z <a target="_blank" rel="noopener noreferrer" href="https://www.uni-muenster.de/en/">University of Münster</a>&nbsp;založí svoji výzkumnou skupinu na <a target="_blank" rel="noopener noreferrer" href="https://www.muni.cz/">Masarykově univerzitě</a> v Brně, kterou od ledna 2027 podpoří start-up grant Nadace Experientia ve výši 6 600 000 Kč. Se svým týmem bude vyvíjet nové strategie pro stavbu molekul tak, aby vznikala výhradně jejich žádoucí zrcadlová podoba.<a target="_blank" rel="noopener noreferrer" href="https://www.experientia.cz/zahranicni-staze/chceme-zefektivnit-vyzkum-v-oblasti-novych-materialu-i-leciv">Tereza Edlová </a>z <a target="_blank" rel="noopener noreferrer" href="https://www.vscht.cz">VŠCHT Praha</a> díky stipendiu ve výši 1 260 000 Kč vycestuje na roční stáž na britskou <a target="_blank" rel="noopener noreferrer" href="https://www.manchester.ac.uk">University of Manchester</a> do skupiny prof. Igora Larrosy, kde se bude věnovat projektu, který může zefektivnit výzkum v oblasti materiálů i léčiv.<a target="_blank" rel="noopener noreferrer" href="https://www.experientia.cz/zahranicni-staze/nase-metoda-by-mohla-urychlit-vyvoj-novych-leku">Ladislav Prener </a>z <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/cs">ÚOCHB AV ČR</a> získal stipendium ve výši 1 200 000 Kč a zamíří na německou <a target="_blank" rel="noopener noreferrer" href="https://www.rwth-aachen.de/cms/~a/root/?lidx=1">RWTH Aachen University</a> do skupiny prof. Leonoriho. Na své roční stáži bude vyvíjet metodu, která by mohla urychlit vývoj nových léků.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Nadace_Experientia_Nadace_Experientia_zna_drzitelku_start_up_grantu_a_stipendisty_pro_rok_2026_c96fdf9a4f.jpg" alt="Nadace Experientia: Nadace Experientia zná držitelku start-up grantu a stipendisty pro rok 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Nadace_Experientia_Nadace_Experientia_zna_drzitelku_start_up_grantu_a_stipendisty_pro_rok_2026_c96fdf9a4f.jpg 234w," sizes="100vw" width="600" height="400"><blockquote>Nadace Experientia od roku 2012 podpořila už 27 nadějných mladých vědkyň a vědců, kteří díky stipendiu dostali šanci vycestovat na roční stáž na špičková zahraniční vědecká pracoviště. Díky programu start-up grantů si mohlo dalších 6 mladých vědkyň a vědců založit po návratu ze zahraničí vlastní výzkumnou skupinu v ČR. Celkem už na podporu mladých vědkyň a vědců vyčlenila Nadace Experientia více než 73 milionů korun.</blockquote></div></div>

Nadace Experientia zná držitelku start-up grantu a stipendisty pro rok 2026

V týdnu od 29. června na Vás čekají v oblasti kapalné fáze a především HPLC a LC/MS následující webináře.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://www.lcms.cz/webinars">👉 DETAILY A REGISTRACE V SEKCI WEBINÁŘE</a></h4></blockquote><blockquote>👉 Vyhledávejte a filtrujte v největší globální databázi s více než 5 500 GC, HPLC, MS a spektroskopickými webináři.</blockquote><h5>1. Thermo Fisher Scientific: Insights from an IC Specialist: To Be Suppressed or Not Suppressed?</h5><ul><li>Út, 30.6.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6310">Registrace</a></li></ul>Zjistěte, jak technologie supresorů ovlivňuje citlivost, selektivitu, spolehlivost i nároky na údržbu v iontové chromatografii. Webinář představí výhody i omezení potlačené a nepotlačené vodivostní detekce a nabídne praktické tipy pro řešení běžných problémů.<h5>2. SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery</h5><ul><li>Út, 30.6.2026 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6311">Registrace</a></li></ul>Objevte možnosti hmotnostní spektrometrie ZenoTOF pro proteomiku jednotlivých buněk i analýzu plazmatických biomarkerů. Přednáška ukáže, jak vysoké rozlišení a citlivost urychlují biologický výzkum a objevování nových biomarkerů.<h5>3. Agilent Technologies: Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres</h5><ul><li>Út, 30.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6052">Registrace</a></li></ul>Naučte se správně měřit difúzní transmitanci a reflektanci pomocí UV/VIS spektrometrů s integrační koulí. Webinář představí praktické využití systému Cary 60 při analýze široké škály materiálů.<h5>4. Waters Corporation: Informatics Series #33: Tips, Tricks and Best Practices</h5><ul><li>Čt, 2.7.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6315">Registrace</a></li></ul>Interaktivní lekce zaměřená na software Empower představí užitečné funkce, klávesové zkratky a osvědčené pracovní postupy, které pomohou zrychlit každodenní práci a zvýšit efektivitu zpracování chromatografických dat.<h5>5. Waters Corporation: Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS</h5><ul><li>Čt, 2.7.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6313">Registrace</a></li></ul>Zjistěte, jak cyklická iontová mobilita rozšiřuje možnosti charakterizace terapeutických peptidů a analogů GLP-1. Webinář ukáže přínosy této technologie pro vývoj léčiv, kontrolu kvality i regulatorní dokumentaci.<h5>6. Agilent Technologies: Spectral Flow Cytometry Masterclass – Session 1</h5><ul><li>Pá, 3.7.2026 07:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/webinar/6316">Registrace</a></li></ul>První část odborné série představí principy spektrální průtokové cytometrie, návrh experimentů a praktické aplikace v imunologii, onkologii i výzkumu vakcín.

Webináře LabRulezLCMS týden 27/2026

Webináře

Popularizace

Věda a výzkum

Video

Článek

Podporujeme mladé vědkyně a vědce z oboru organické, bioorganické a medicinální chemie na zahraničních stážích i zde v ČR díky tzv. start-up grantům Nadace Experientia.

Nadace Experientia

ÚOCHB AV ČR je přední mezinárodně uznávaná vědecká instituce, jejímž hlavním posláním je základní výzkum v oblasti chemické biologie a medicinální chemie, organické a materiálové chemie, chemie přírodních látek, biochemie a molekulární biologie, fyzikální chemie, teoretické chemie a analytické chemie.

Ústav organické chemie a biochemie AV ČR

Vše ze světa analytické chemie na jednom místě. Propojujeme lidi při řešení jejich problémů. U nás naleznete všechny potřebné informace snadno, rychle a přehledně. Přestaňte hledat a začněte nacházet.

LabRulez

Separation Science

Agilent Technologies

Bruker

Thermo Fisher Scientific

SCIEX

Waters Corporation

UV/VIS spectrometers are traditionally used for well-dissolved solutions measured in cuvettes. However, one of the most common UV/VIS accessories is an integrating sphere. With an integrating sphere, it is possible to measure almost any sample – including opaque solids, powders, gels, and turbid solutions. This webinar will discuss diffuse transmission and reflection UV/VIS measurements including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer and a diffuse reflectance accessory (DRA).<blockquote>Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.</blockquote>

Agilent Technologies: Molecular spectroscopy webinars

Measuring Diverse Samples with UV/VIS Spectrometers and Integrating Spheres

Webinar will discuss diffuse transmission and reflection UV/VIS measurements including how to perform measurements with Agilent’s Cary 60 UV/VIS Spectrometer

Measuring Diverse Samples with UV/VIS Spectrometers

As a global leader in ion chromatography (IC), Thermo Fisher Scientific is committed to helping laboratories optimize their IC workflows and achieve reliable, high-quality analytical results.In 2026, we are hosting a series of Ask the Experts sessions designed to provide practical guidance on key aspects of IC analysis. Each session features a focused technical presentation from an IC specialist, followed by dedicated time to discuss attendee-submitted questions. &nbsp;Our second Ask the Experts session will focus on the critical role suppressors play in IC performance, sensitivity, and reliability. Topics will include:<ul><li>How suppressor technology has evolved and why it matters for modern IC workflows</li><li>When suppression is necessary — and how to determine the best approach for your application</li><li>Key considerations for selecting the right suppressor</li><li>Best practices for suppressor care, maintenance, and troubleshooting</li></ul>Whether you are optimizing an existing method, troubleshooting performance issues, or evaluating new applications, this session will provide practical insights to help you improve suppressor performance and get more from your IC system.We invite you to help shape our IC discussion by submitting questions in advance by using this form.<blockquote>Speaker: Bart Cleeren (Product Marketing Manager, Thermo Fisher Scientific)Bart has an extensive background as an experienced separation scientist and expert in ion chromatography. As a business development manager and product marketing manager at Thermo Fisher Scientific, Bart has supported customers using ion chromatography across a variety of industries. He has a postgraduate degree in Business Economics from VLEKHO Business School in Brussels and a Master of Science in Applied Analytical Chemistry from PHITS in Antwerp.Speaker: Wai-Chi Man (Product Marketing Manager, Thermo Fisher Scientific)Wai-Chi has been with Thermo Fisher Scientific for more than eight years working with a wide range of customers in various industries. She provides ion chromatography (IC) support in method development, troubleshooting, sample preparation, training, seminars, events, and workshops. During this time, she has gained deep knowledge, skill, and understanding in areas such as IC-MS, IC-ICP-MS, carbohydrate analysis, metabolomics, and polar pesticides. Prior to joining the company, she worked for Wellcome Research and GlaxoSmithKline. Wai is passionate about promoting STEM to future scientists by encouraging, nurturing, and supporting them.</blockquote>

Thermo Fisher Scientific: Insights from an IC specialist: To be suppressed or not suppressed?

Insights from an IC specialist: To be suppressed or not suppressed?

Learn suppressor selection, maintenance, and troubleshooting strategies to improve ion chromatography performance and reliability.

Insights from an IC specialist

Join us for an insightful webinar on how ZenoTOF-based high‑resolution mass spectrometry workflows are advancing both high‑throughput single‑cell proteomics and plasma biomarker discovery.The session will highlight enhanced detection sensitivity, increased throughput, and automation in sample preparation, alongside insights into plasma proteomics workflows, enrichment strategies, and protein quantification. Key considerations in data analysis and biomarker identification for pregnancy complications will also be discussed.<blockquote>Speaker:&nbsp;Dr. Dipankar Malakar (Application support manager, SCIEX)Dr. Dipankar Malakar is a seasoned mass spectrometry and life sciences professional with extensive experience at SCIEX. With a strong research background from the Indian Institute of Chemical Biology (IICB), Kolkata, he has contributed significantly to advancing analytical workflows in metabolomics, proteomics, and high-resolution mass spectrometry.Key highlights<ul><li>Higher Detection Sensitivity</li><li>Higher Throughput</li><li>Automation in Sample Preparation</li></ul>Speaker: Dr. Tushar Maiti (Professor, Regional Centre for Biotechnology, NCR Biotech, Faridabad., Secretary of the Proteomics Society, India)Dr. Tushar Maiti is a distinguished researcher and Professor at the Regional Centre for Biotechnology (RCB), Faridabad. With a Ph.D. from IIT Kharagpur and serving as Secretary of the Proteomics Society, India, he has made significant contributions to the fields of protein quality control, neurodegenerative diseases, and clinical proteomics.Key highlights<ul><li>Plasma proteomics workflow using ZenoTOF7600 system</li><li>Discussion on neat plasma vs various enrichment technologies</li><li>Protein Quantification using HR-MRM of potential markers</li><li>Challenges in the data analysis</li></ul></blockquote>

SCIEX: Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery

Advancing Proteomics with ZenoTOF: From Single-Cell Analysis to Plasma Biomarker Discovery

Learn how ZenoTOF workflows improve single-cell proteomics, plasma biomarker discovery, protein quantification, and data analysis.

Advancing Proteomics with ZenoTOF

Are you working with therapeutic peptides such as GLP-1 analogues and looking for more powerful characterisation tools to support your development pipeline or regulatory submissions?GLP 1 analogues are complex molecules, and generating the analytical insight needed to support development and regulatory submissions can be challenging.Regulatory agencies expect comprehensive analytical characterisation of therapeutic peptides, including peptide structure, purity, impurities and stability. For GLP 1 analogues, this is particularly challenging because these molecules can be susceptible to chemical and conformational change, and many include structural modifications that increase analytical complexity compared with traditional small molecules.Join us for a focused webinar on how cyclic ion mobility spectrometry (cyclic IMS) is enabling exactly that level of insight with the resolution and confidence required for both R&amp;D and submission-ready data packages.<h4>What you will learn</h4><ul><li>Why cyclic IMS outperforms conventional ion mobility for peptide analysis</li><li>Characterising GLP-1 and related therapeutics: conformers, isomers, and beyond</li><li>Building a robust analytical framework to meet FDA and EMA expectations</li></ul>Can't attend the webinars live? Register today and watch the episodes on-demand at your convenience.<blockquote>Speaker: Dale Cooper-Shepherd (Principal Consulting Scientist, Waters Corporation, UK)Dale Cooper Shepard specialises in ion mobility‑mass spectrometry, with particular expertise in cyclic IMS. His work focuses on applying advanced separation techniques to improve resolution of complex mixtures and enable deeper structural insights, supporting challenging analyses in areas such as bioanalysis and pharmaceutical research.Speaker: Antonia Wierzbicki (Principal MS Market Dev Manager, EMEA, Waters Corporation)Antonia has BSc in Pharmaceutical Science and a MSc in Cancer Pharmacology.Following several years working as an analytical chemist in drug development roles within both academic labs and contract research organizations, Antonia has more recently spent time working with analytical chemists to provide solutions using cutting edge technologies to meet their needs and requirements, with a specific interest in ultra-sensitive quantitation of small molecules.Antonia is based in Cambridge UK and keen to connect with like-minded scientists in the field.</blockquote>

Unlocking Therapeutic Peptide Characterisation (GLP-1RAs) with Cyclic IMS

Learn how cyclic IMS enhances GLP-1 peptide characterization, enabling confident analysis of conformers, isomers, impurities, and stability.

Therapeutic Peptide Characterisation with Cyclic IMS

<h4>How about a 30 minute coffee break along with a bite of Empower?</h4>Here you go!Whether you are just getting started with Empower Software or have years of experience dating back to earlier chromatography platforms, there are often powerful capabilities that go unused or are easily overlooked. This interactive session revisits essential features, shortcuts, and practical techniques that can streamline everyday laboratory work and reduce unnecessary effort.<h5>What you will learn:&nbsp;</h5><ul><li>Work efficiently across multiple projects using Global Project View&nbsp;</li><li>Apply view filters to quickly find and analyze relevant data&nbsp;</li><li>How to use information displayed in the Mass Analysis window&nbsp;</li><li>Leverage analytics to gain insight into lab operations</li></ul>Prepare a coffee and attend!<blockquote>Speaker: Ralf Schröder (Informatics Market Development Manager)Speaker: Carsten Fischer (Informatics Product Marketing, EMEA)</blockquote>

Informatics series #33 Tips, Tricks and Best Practices

Session revisits essential features, shortcuts, and practical techniques in Empower software that can streamline everyday laboratory work

Modern biopharma pipelines are rapidly expanding beyond conventional monoclonal antibodies into multi‑specific formats and bioconjugates such as antibody–drug conjugates (ADCs) and antibody–oligonucleotide conjugates (AOCs). While these modalities unlock new therapeutic possibilities, their structural complexity significantly increases analytical demands. Molecular assembly, chain pairing, size, charge, and hydrophobic heterogeneity, post-translational modifications, and stability can all vary in subtle yet clinically meaningful ways. &nbsp;In this webinar, we present a practical, end‑to‑end characterization framework that connects LC-based strategies across structural levels—intact, subunit, and peptide—and shows how orthogonal separations support confident decisions from development through QC transfer. Topics include approaches to verify structural integrity, reveal mispaired or incorrectly assembled species, monitor size variants and aggregation, assign charge variants, and apply fit‑for‑purpose workflows to conjugated antibodies where additional heterogeneity must be controlled.Attendees will leave with a clear “analytical toolbox” perspective—understanding which techniques to apply, what questions each method answers, and how to assemble robust characterization strategies for emerging antibody modalities.<h4>What you'll learn</h4><ul><li>How multispecific formats and conjugates change analytical strategy vs. traditional mAbs</li><li>How LC separates and quantifies variants, while LC–MS enables molecular confirmation</li><li>How to align intact, subunit, and peptide workflows to specific analytical questions</li><li>How conjugation introduces new heterogeneity—and how to manage it effectively (ADC/AOC)</li></ul><h4>Why attend?</h4>As antibody therapeutics evolve from conventional mAbs to multi‑specific architectures and bioconjugates (ADCs and AOCs), analytical teams face complexity—more variants, more heterogeneity, and a greater need for orthogonal evidence to support confident development and control strategies.In this webinar, we share a pragmatic characterization roadmap using LC-based methods across intact, subunit, and peptide‑mapping workflows—showing how each layer answers different questions, and how to assemble them into a cohesive package.<h4>Key takeaways include:</h4><ul><li>Selecting LC/LC‑MS approaches for size, charge, and hydrophobic variants,</li><li>Detecting mispaired or incorrectly assembled multi‑specific species</li><li>Handling the added complexity of conjugated antibodies (ADC/AOC) within fit‑for‑purpose workflows</li></ul>Ideal for scientists in analytical development, CMC, and QC supporting next‑generation antibody therapeutics.<h4>Who should attend?</h4>Analytical scientists in biopharma R&amp;D, process development, and QC working with advanced antibody modalities.You can select the language of the content in the top right corner of your screen. This webinar will be delivered in English.<blockquote>Speaker: Ali Tiss, Ph.D., MSc., Eng. (Chat) (Chemistry Market Development Manager, Biopharma &amp; Cell and Gene Therapies, Waters Corporation)Ali joined Waters in 2021 and has since supported colleagues and users in the biomolecule separation field (proteins, peptides, Abs, conjugates, Cell &amp; Gene Therapy products). Ali completed his Ph.D. in biochemistry and structural biology at the Mediterranean University (CNRS, Marseille, France), where he contributed to the R&amp;D of the anti-obesity drug, Xenical®, developed by Roche Ltd. Then, he earned over two decades of research experience in biochemistry, liquid chromatography, mass spectrometry, and proteomics, focusing on detecting and characterizing biomarkers related to human diseases such as cancer, diabetes, and obesity. Ali is passionate about supporting customer business and innovative applications.</blockquote>

Characterizing Next-Generation Antibody Therapeutics: LC Strategies for Multispecifics, ADCs & AOCs

In this webinar, we share a pragmatic characterization roadmap using LC-based methods across intact, subunit, and peptide‑mapping workflows

LC Strategies for Multispecifics, ADCs & AOCs

The presence of antibiotics in aquatic environments is a growing analytical challenge, with trace-level contamination posing significant risks to ecosystems and contributing to antimicrobial resistance. Accurate, reliable and high-throughput sample preparation is therefore essential for effective water quality monitoring.This webinar will demonstrate the use of the Biotage® PrepXpert-8 automated solid-phase extraction (SPE) system for the simultaneous extraction and enrichment of multiple antibiotic classes, including fluoroquinolones, tetracyclines, sulfonamides and macrolides from water matrices.We will cover method development considerations, sorbent selection and the advantages of full automation in reducing operator variability and improving reproducibility. Quantitative data and method performance metrics will be presented and discussed.Whether you are new to SPE or looking to streamline existing workflows, this webinar offers practical insights for modern environmental water analysis.By attending this presentation, you will:<ul><li>Gain practical knowledge of automated SPE method development for extracting multiple antibiotic classes from water matrices using the Biotage® PrepXpert-8.</li><li>Learn key sorbent selection strategies and see real quantitative recovery data to support your own method implementation.</li><li>Leave equipped to streamline your sample preparation workflows and improve reproducibility in water analysis.</li></ul><h5>Who should attend?</h5>This webinar is ideal for analytical and environmental chemists, water quality scientists and laboratory managers working in environmental monitoring, regulatory compliance, or pharmaceutical research who are involved in trace-level contaminant analysis.<h5>What you need to know:</h5>Start times:<ul><li>Broadcast 1: 8 am BST (London/Lisbon) / 9 am CEST (Paris/Berlin) / 12:30 pm IST (New Delhi) / 3 pm CST (Beijing) / 4 pm JST (Tokyo)</li><li>Broadcast 2: 8 am CDT (Chicago) / 9 am EDT (New York) / 2 pm BST (London/Lisbon) / 3 pm CEST (Paris/Berlin)</li><li>Broadcast 3: 10 am PDT (Los Angeles) / 12 pm CDT (Chicago) / 1 pm EDT (New York)</li></ul>Duration: 1 hour<blockquote>Presenter: Vainius Skukauskas (Applications Chemist, Biotage EMEA Application Laboratory, Cardiff, UK)Dr. Vainius Skukauskas is an Applications Chemist at the Biotage EMEA Application Laboratory in Cardiff, UK. With a Ph.D. in chemistry and extensive expertise in analytical method development, he specializes in developing and optimizing automated sample preparation workflows across a wide range of industries, with a particular focus on the environmental and food sectors. He works closely with customers to translate complex methods into robust, high-throughput solutions, and regularly delivers technical demonstrations, training, and workshops across EMEA.</blockquote>

Separation Science: Advances in Antibiotic Extraction from Water - An Automated SPE Approach

Advances in Antibiotic Extraction from Water: An Automated SPE Approach

Advance water quality monitoring. Discover automated SPE method development and sorbent selection for trace-level antibiotic extraction with Biotage

Automated SPE Approach for Antibiotic Extraction from Water

Join us for an insightful webinar on the analysis of Per- and Polyfluoroalkyl Substances (PFAS) in food substances using advanced LC-MS/MS technology. This session will cover the importance of PFAS testing in food safety, key analytical challenges, sample preparation strategies, method development approaches, and best practices for accurate and sensitive detection using LC-MS/MS systems. Experts will also discuss workflow optimization, regulatory considerations, and real-world applications across different food matrices, helping laboratories and researchers strengthen their PFAS analysis capabilities.<h5>Key highlights:</h5><ul><li>PFAS in food and it’s regulation around the world</li><li>Analytical challenges &amp; SCIEX LC-MS/MS solutions</li><li>QTRAP workflow to confirm the true or false results in food samples &nbsp;</li></ul><blockquote>Expert: Kankan Jana (Application Support Specialist, SCIEX)</blockquote>

SCIEX: Analysis of per- and polyfluoroalkyl substances (PFAS) in food substances using LC-MS/MS solutions

Analysis of per- and polyfluoroalkyl substances (PFAS) in food substances using LC-MS/MS solutions

Advance food safety testing. Discover SCIEX LC-MS/MS methods and QTRAP workflows for accurate detection and regulatory compliance of PFAS in food

PFAS Analysis in Food Safety: SCIEX LC-MS/MS Solutions

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Leverage unique capabilities and powerful tools to streamline sample analysis. Are you using your Thermo Scientific Vanquish UHPLC systems to their fullest potential?Join this webinar to discover the multiple tools in Thermo Scientific Chromeleon software that drive sample throughput from acquisition to data processing and deliver reduced errors through advanced automation.<h4>Why attend</h4>Uncover the Chromeleon software features that drive sample throughput and deliver unique capabilities in combination with the Thermo Scientific Vanquish Duo UHPLC system. In this webinar, you will see how Chromeleon software can help:<ul><li>Increase sample throughput through streamlined workflows</li><li>Leverage the full capabilities of the Vanquish Duo UHPLC system&nbsp;</li><li>Deliver automation to common analyses to reduce errors</li></ul>Through practical examples and live software demonstrations, attendees will learn how to improve day-to-day laboratory efficiency and reduce errors.<h4>What you will learn</h4>By attending, participants will be able to:<ul><li>Streamline analysis in Chromeleon software from acquisition to result</li><li>Understand and leverage the unique capabilities of Vanquish Duo UHPLC systems &nbsp;</li><li>Drive automation in common workflows to reduce errors</li></ul>Save your spot to discover practical ways to optimize Vanquish UHPLC system workflows with Chromeleon software.Cannot attend on July 9? Please register anyway to automatically receive the link to the recording.<blockquote>Presenter: Darren Barrington-Light (Senior Manager, Product Marketing, Thermo Fisher Scientific)Darren Barrington-Light’s background includes over 25 years of experience in the field of analytical chemistry, chromatography hardware and computer software. Having worked in chromatography throughout his career, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, he has worked with clients across multiple industries to show them how software solutions can help them to improve their day to day operations and drive fast, informed decisions.</blockquote></div></div></div>

Thermo Fisher Scientific: Advanced tools to maximize your sample throughput with Chromeleon Software and Vanquish UHPLC

Advanced tools to maximize your sample throughput with Chromeleon Software and Vanquish UHPLC

Discover how Chromeleon software optimizes Vanquish UHPLC workflows with automation, higher throughput, and reduced errors from acquisition to results.

Sample throughput with Chromeleon and Vanquish UHPLC

Advances in metabolomics and lipidomics are generating unprecedented volumes of complex data, but confident identification and biological interpretation of small molecules remain significant challenges. Limitations in annotation, data dimensionality, and reproducibility can slow discovery and reduce confidence in downstream decision making across clinical, translational, and applied research.In this live broadcast event, leading experts explore how next generation mass spectrometry technologies, ion mobility, and computational tools are helping researchers move from complex datasets to confident insight. Through three short, focused scientific talks, speakers will share real world examples of how multi dimensional data and advanced workflows are being used to improve metabolite and lipid annotation, accelerate small molecule discovery, and enable more robust and reproducible analyses.<h4>Who Should Attend</h4><ul><li>Untargeted metabolomics and natural products researchers focused on spectral annotation and structure elucidation</li><li>Microbiome, exposomics, and environmental health scientists&nbsp;</li><li>Drug discovery scientists using AI/ML and computational chemistry</li><li>Core facility managers and method developers building reproducible, multi-dimensional LC-MS/MS workflows</li><li>Cheminformatics and computational scientists working with spectral repositories and ML-based metabolite prediction</li><li>Lab leaders evaluating next-generation ion mobility MS platforms for 4D-metabolomics and 4D-lipidomics</li></ul><h4>Key Learning Objectives</h4><ul><li>How to boost identification confidence and speed using timsMetabo™, isotope‑based filtering, and MassQL</li><li>Applying multi‑dimensional data (including ion mobility and CCS) to improve metabolite annotation</li><li>Tips for accelerating small‑molecule discovery and lipidomics workflows with robust, reproducible approaches</li><li>Navigating current bottlenecks in non‑targeted and targeted metabolomics and lipidomics</li></ul><blockquote>Speaker: PD Dr. Michael Witting, Deputy Head Metabolomics and Proteomics Core &amp; Executive Manager Metabolomics, Helmholtz Munich, Munich, GermanySpeaker: Pieter Dorrestein, Professor, Skaggs School of Pharmacy and Pharmaceutical Sciences Departments of Pharmacology and Pediatrics, UC San Diego, San Diego, CA, USASpeaker: Pelle Simpson, Principal Scientist, Enveda, Boulder, CO, USA</blockquote>

Bruker: 4D-Metabolomics™ in Action: Real‑World Strategies for Deep Discovery and Confident Annotation

4D-Metabolomics™ in Action: Real‑World Strategies for Deep Discovery and Confident Annotation

Next generation mass spectrometry technologies, ion mobility, and computational tools are helping researchers move from complex datasets to confident insight. 

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