25. Škola hmotnostní spektrometrie 2024 - finální program

<div class="___1mdw7yc f22iagw f1vx9l62 f2qmhz0"><p><strong>Zajímáte se o vliv chemických látek na životní prostředí a hledáte odborné informace z první ruky? S velkým potěšením Vás zveme na náš nově připravovaný webinář zaměřený na testování ekotoxicity. Webinářem Vás provede supervizorka ekotoxikologické sekce ALS Czech Republic a odbornice na danou problematiku, Kateřina Vavřinová.</strong></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Náš nový webinář zaměřený na <strong>testy ekotoxicity</strong>, Vám poskytne hlubší vhled do této problematiky. Na začátku se seznámíme se <strong>základními pojmy a principy ekotoxicity</strong>, následně se podíváme na <strong>metodologii testování</strong>, a nedílnou součástí webináře bude samozřejmě také <strong>přehled legislativního rámce</strong>, kde probereme aktuální <strong>předpisy a vyhlášky ovlivňující testování ekotoxicity</strong>.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Pomocí praktických ukázek Vám představíme <strong>konkrétní příklady a postupy testování</strong>, které vám pomohou aplikovat získané znalosti v praxi.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Na závěr webináře budete mít možnost položit Kateřině otázky formou chatu.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Těšíme se na Vaši účast a diskusi na toto velmi aktuální téma.</span></p><h5><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv"><strong>Pro koho je webinář určen?</strong></span></h5><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Tento webinář je vhodný pro širokou škálu účastníků, kteří mají o problematiku ekotoxicity a kvality životního prostředí zájem. Rádi přivítáme naše klienty, ekology, odborníky a vědce v&nbsp;oblasti odpadového hospodářství, pracovníci státní správy, laboranty nebo studenty.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Zaujal Vás tento připravovaný webinář? Zúčastněte se a můžete si tak rozšířit své znalosti o testování ekotoxicity.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Rádi byste se zúčastnili, ale nevyhovuje Vám termín online přenosu? Nevadí! Zaregistrujte se i v&nbsp;tomto případě, záznam <strong>webinář bude pro všechny registrované účastníky dále k&nbsp;dispozici ze záznamu</strong>.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Těšíme se na Vás.</span></p><p><span class="fui-Text ___1kd1avm fk6fouc fod5ikn faaz57k figsok6 fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 ___123018q ftyhbck f1nt3iuv">Váš tým ALS.</span></p></div><blockquote><p><strong>Přednášející:</strong> <span class="fui-Text ___1y6hpew fk6fouc fkhj508 fj15ycj figsok6 fpgzoln f22iagw f6juhto f1mtd64y f1y7q3j9 f2jf649 f1q5m4vj f122n59 ___ecjtiy0 f1pp30po fl43uef f1o700av f1w7gpdv fmrv4ls">Kateřina Vavřinová (</span><span class="fui-Text ___1vn0vlm fk6fouc fod5ikn faaz57k fdj6btp fpgzoln f1w7gpdv f6juhto f1mtd64y f1y7q3j9 f2jf649 f11d4kpn">Ecotoxicology Section SupervisorALS Czech Republic s.r.o.)</span></p></blockquote><div class="___1ssnlw3 f22iagw f1vx9l62 f1nicjmu fly5x3f f1l02sjl"><div class="___k6j0wd0 f22iagw f1nicjmu f1vx9l62"><blockquote><div class="___kwg7oq0 f197wrh9 fpfc2by f1rvi9lw f1p9o1ba f1sil6mw f1cmbuwj fokg9q4"><span class="fui-Text ___58amfs0 fk6fouc fod5ikn f1i3iumi figsok6 fpgzoln f1w7gpdv fibxuh5 f1mtd64y f1y7q3j9 f2jf649">Kateřina Vavřinová pracuje jako supervizorka ekotoxikologické sekce v laboratořích ALS v České Lípě.</span></div></blockquote></div></div>

Webinář ALS Czech Republic: Ekotoxicita

<p><strong>Rádi bychom Vás pozvali na jednodenní hybridní konferenci, která se zaměří na nejnovější trendy a inovace v analýze mikroplastů. Dopolední program bude online přenášen a nahráván, což umožní virtuální účast pro ty, kteří se nemohou zúčastnit osobně.</strong></p><h3><strong>Program</strong></h3><p><strong>Dopolední část: </strong>Bude zaměřena na klíčové poznatky o <a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/library?mainauthorItems=10&amp;search=microplastics"><strong>analýze mikroplastů</strong></a>, stejně jako o <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/library?mainauthorItems=10&amp;search=PFAS"><strong>PFAS</strong></a> a dalších kontaminantech životního prostředí, prostřednictvím prezentací špičkových výzkumníků a odborníků z oboru.</p><p><strong>Odpolední část:</strong> Bude zaměřena na interaktivní <strong>workshopy</strong>, jejichž cílem je zlepšit vaše praktické dovednosti v přípravě vzorků. To poskytuje jedinečnou příležitost zvládnout pokročilé techniky a metodiky pod vedením profesionálů. Navštivte živé demo na IR QCL založeném na <a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/products/719"><strong>8700 LDIR</strong></a>. Kromě toho si užijte prohlídku laboratoře s průvodcem, která nabízí exkluzivní pohled do nejmodernějších zařízení v kampusu HEREON.</p><h5>9:15 a.m. - Welcome</h5><h5>9:20 a.m. - <strong>From Macroplastics to Mesoplastics: Challenges and Solutions</strong></h5><ul><li>Dr. Marion Börger, Agilent Technologies,</li><li>Dr. Andreas Kerstan, Agilent Technologies</li></ul><h5>9:40 a.m. - <strong>i3 Membrane Session: Filter Membranes/Packaging - Jacobs</strong></h5><ul><li>Kathrin Hahn, i3 Membrane</li></ul><h5>10:00 a.m. - <strong>Exploring Microplastic Sources and Distribution in Australian Soils</strong></h5><ul><li>Subharthe Samandra, University of Melbourne</li></ul><h5>10:20 a.m. - <strong>Advancing Analysis: Eurofins' Path to ISO 17025 Accreditation for Microplastics Testing</strong></h5><ul><li>Julia Jäger, Eurofins</li></ul><h5>10:40 a.m. - Coffee Break</h5><h5>11:00 a.m. - <strong>Validation and Application of LDIR Imaging to Analyze Microplastics in Marine Samples</strong></h5><ul><li>Lars Hildebrandt, Hereon</li></ul><h5>11:20 a.m. - <strong>Applying Multiple Analytical Techniques to Answer Open Questions About Offshore Wind</strong></h5><ul><li>Alexa Zonderman, Hereon</li></ul><h5>11:40 a.m. - <strong>Sample-Based Subsampling Strategies to Analyze Large Quantities of Particles in LDIR</strong></h5><ul><li>Manuel Andrade, University La Coruna</li></ul><h5>12:00 p.m. - <strong>Beyond the Surface: Spotlight on Plastic [Metal(loid)] Additive Leaching and Unseen Contaminants</strong></h5><ul><li>Ole Klein, Hereon</li></ul><h5>12:20 p.m. - <strong>Microplastics back in food- Advantages of Thermal Desorption for a wide range of Samples</strong></h5><h5>12:40 p.m. - <strong>Struggling with Solvent Effects During the Analysis of PFAS</strong></h5><ul><li>Dr. Axel Ritter, Agilent Technologies</li></ul><h5>1:00 p.m. - Lunch Break</h5><h5>2:00 p.m. - <strong>An Analytical Toolbox to Unravel PFAS Source Fingerprints</strong></h5><ul><li>Frank Menger, Hereon</li></ul><h5>2:20 p.m. - <strong>LDIR for Assessment of Microplastics in the VAMAS Ring Trial and Tissue in a Murine Infection Model</strong></h5><ul><li>Christoph Krafft, IPHT</li></ul><h5>2:40 p.m. - <strong>Label-Free Infrared Spectroscopic Micro- and Nanoplastics Detection in Complex Matrices</strong></h5><ul><li>Markus Brandstetter, Recendt</li></ul><h5>3:00 p.m. - <strong>Break in Dividing the Guests into Subgroups</strong></h5><h5>3:10 p.m. - <strong>Lab Visits: Organic Lab, Microplastics Lab, Sample Prep, LDIR, and Other Techniques</strong></h5><h5>4:50 p.m. - Wrap up</h5><h3><strong>Detaily konference</strong></h3><ul><li><strong>Datum a čas:</strong> 29. října 2024 od 9:00 do 16:30&nbsp;</li><li><strong>Místo konání:</strong> &nbsp;GITZ GmbH, Max-Planck-Straße 2, 21502 Geesthacht, Germany</li><li>Během konference bude zajištěno občerstvení a oběd.</li></ul><p><a target="_blank" rel="noopener noreferrer" href="https://explore.agilent.com/microplameeting24"><span style="font-size:20px;"><strong>Přihlaste se zde</strong></span></a></p><p>Kapacita sálu pro prezenční účast je omezena! Můžete využít i <strong>online připojení do streamu konference</strong>, ale <strong>streamovaná bude jen dopolední část konference</strong>. Odpolední program, tedy workshopy, budou probíhat jen prezenčně na místě.</p><p><strong>Neváhejte a přihlaste se!&nbsp;</strong></p><blockquote><h3><a target="_blank" rel="noopener noreferrer" href="https://icpms.cz/products/719"><strong>Agilent 8700 LDIR chemický zobrazovací systém</strong></a></h3><p>Agilent 8700 Laser Direct Infrared (LDIR) chemický zobrazovací systém poskytuje nový sofistikovaný přístup k chemickému imagingu a infračervené spektrální analýze. 8700 LDIR byl vyvinut pro použití jak experty, tak laiky a nabízí jednoduchý vysoce automatizovaný postup pro dosažení spolehlivých vysoce rozlišených chemických zobrazení jednotlivých povrchových složek.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HPST_Obr_1_Agilent_8700_LDIR_system_pro_chemicky_imaging_19f4f9f649/HPST-Obr.-1-Agilent-8700-LDIR-system-pro-chemicky-imaging.jpg" alt="Altium: Agilent 8700 LDIR systém pro chemický imaging" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HPST_Obr_1_Agilent_8700_LDIR_system_pro_chemicky_imaging_19f4f9f649/thumbnail_HPST-Obr.-1-Agilent-8700-LDIR-system-pro-chemicky-imaging.jpg 245w," sizes="100vw" width="1554" height="684"></p></blockquote>

Agilent Microplastics Meeting 2024 (žive + online)

Webináře

Životní prostředí

Zdraví

Toxikologie

Article

Článek

Video

Nejbližší akce

Škola hmotnostní spektrometrie je odborná vzdělávací akce pořádaná od roku 1986, která vedle zajímavých přednášek a kurzů nabízí i nespočet příležitostí k přátelským setkáním a diskusím.

Škola hmotnostní spektrometrie

Základním posláním společnosti ALS je pomáhat našim klientům se kvalifikovaně a informovaně rozhodovat tím, že poskytuje spolehlivá, konzistentní a reprodukovatelná laboratorní data. Zaručujeme spolehlivé výsledky, krátké dodací lhůty, nepřetržitý provoz, odbornou podporu a odběry vzorků.

ALS Czech Republic

Je autorizovaným distributorem společnosti Agilent Technologies pro Českou republiku v oblastech chromatografie (GC, HPLC, UHPLC, kapilární elektroforéza) a hmotnostní spektrometrie (GC/MS, LC/MS, CE/MS), disolučních aparátů, molekulární (UV-Vis, UV-Vis-NIR, fluorescence, FTIR analyzátory a mikroskopy) a atomové spektroskopie (ICP-OES, ICP-MS, AAS), a v neposlední řadě také v oblasti molekulární biologie a genomiky (analýza nukleových kyselin a proteinů, microarray skenery a skla, PCR & RT-PCR, qPCR, řešení pro NGS, reagencie pro mutagenezi a klonování, sondy FISH a další).

Altium International

Agilent Technologies

Technology Networks

Bruker

Thermo Fisher Scientific

SCIEX

Waters Corporation

<h4><strong>Virtual event: Pharma conclave series 2024</strong></h4>
<p>SCIEX offers the platform for the experts to take the stage and drive technological progress</p>
<p><strong>Welcome to Pharma conclave series 2024</strong> – where our customers’ expertise meets innovation, transforming your knowledge and empowering you to revolutionize your work processes. Join us in discovering techniques that will enhance your skills to accelerate your daily operations in the development of new drugs.</p>
<p>From the research of new markers to the drug development moving into non and GLP bioanalysis. Confidently plan your next lab expansion with the knowledge gained from industry leaders and pioneers.</p>
<ul>
<li>May 16 <strong>Event 1: Pharma omics</strong></li>
<li>September 17 <strong>Event 2: Impurities</strong></li>
<li>October 23-24 <strong>Event 3: Pharma</strong></li>
</ul>
<p><strong>10:00 a.m.–12:00 p.m. CET</strong></p>
<h3><strong>Event 2: Impurities</strong></h3>
<p><strong>Impurities in the pharmaceutical industry. What&#39;s next?</strong></p>
<p>While the regulatory landscape is changing faster than ever, having the right information on impurities available to you at every stage of the drug development is vital to bring safe and effective therapies to the market. Whether you want to optimize your lab’s current capabilities or scale up to meet your future demands, this event creates a platform to share the customer’s expertise.</p>
<blockquote>
<p><strong>Presenter:</strong> Bruno Manadas, PhD</p>
</blockquote>
<blockquote>
<p>Dr Manadas is a prominent Cell Biology researcher at CNC-UC since 2017. With expertise in biochemistry, psychology, and biotechnology, he&#39;s authored 130+ publications and led multiple projects. As head of CNC&#39;s Mass Spectrometry node and Associate Editor for Frontiers, he&#39;s contributed significantly to neuroscience and psychiatry. Bruno&#39;s research focuses on cell biology mechanisms, translational biomarker research, and MS-based approaches for studying protein oxidation. He played a pivotal role in establishing the hospital biobank and teaches at the Portuguese Catholic University.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Dorte Bekker-Jensen</p>
</blockquote>
<blockquote>
<p>Dorte is heading the Applications Development team in Proteomics Research at Evosep. She has long-term experience within proteomics and has focused on technology development by developing simple and automated workflows for high-throughput applications.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Stefan Ledinger</p>
</blockquote>
<blockquote>
<p>Stefan has 20 years of experience in the life sciences and diagnostic industries. For the last dozen years, he has been serving various functions within biocrates life sciences ag. Most recently, he has been responsible for the market development for metabolomics solutions in the pharmaceutical and biotech industries. He currently serves as Global Head of Sales. Stefan holds degrees in business administration and bioengineering, combining commercial know-how with a passion for science.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Markus Langsdorf</p>
</blockquote>
<blockquote>
<p>Markus has 14 years of experience in life sciences industries. As he joined biocrates in 2010, he worked for 11 years as application support specialist for biocrates’ metabolomics profiling solutions. 3 years ago he changed his position withing the company to his new function as product manager. Markus studied chemistry and graduated with a PhD in Analytical Chemistry.</p>
</blockquote>


Pharma conclave series 2024: Impurities

<p><strong>As part of the global effort to reduce CO₂ emissions, biofuels are becoming an increasingly important source of green energy.</strong></p>
<p>Quality control testing of biofuels is therefore crucial to ensure the efficiency and reliability of biogas, biodiesel, and fuel ethanol.  </p>
<p>In this webinar you will learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels to enable producers to confidently meet international regulatory requirements and to promote their widespread adoption in both industry and the wider society at large. </p>
<p>Experts from Agilent Technologies will introduce a wide range of analytical testing solutions covering multiple technologies that are routinely used to detect organic and inorganic impurities in biodiesel and enable the stringent quality control of fuel ethanol, biogas and biogas blends to be achieved. The expert panel will be available to answer questions from the audience at the end of the presentation. </p>
<blockquote>
<p><strong>Presenter:</strong> Danny van Oevelen (LC Product Specialist, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Luca Godina (GC &amp; GC/MS Application Specialist, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Sebastien Sannac (Spécialiste produit spectroscopie atomique, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Donald Inglis (Product Specialist EMEAI for FTIR, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Remko van Loon (GC &amp; GC/MS Product Specialist, Agilent Technologies)</p>
</blockquote>


Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future

Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.

Comprehensive Quality Control Testing of Biofuels

<p><strong>Capillary electrophoresis (CE) is transforming viral vector manufacturing for next-generation biopharmaceuticals. Traditionally used for quality control, CE can now be used to profile viral proteins in AAV particles and examine genome integrity during production, thanks to novel sample preparation techniques.</strong></p>
<p>In this webinar, our expert speakers will explore the different ways that CE is advancing biopharmaceutical development. They will also discuss how new reference standards are improving our understanding of genome and protein sizes in viral particles and how this impacts the development of viral vector-based therapies.</p>
<p><strong>Attend this webinar to:</strong></p>
<ul>
<li>See how CE is being utilized to profile viral proteins in AAV particles during manufacturing</li>
<li>Discover how CE is instrumental in examining the genome integrity of viral particles throughout production</li>
<li>Explore how the adoption of new reference standards is enhancing the understanding of genome and protein sizes during viral particle manufacturing</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Yolande Masson (Analytical Scientist at Yposkesi, an SK Pharmteco Company)</p>
</blockquote>
<blockquote>
<p>After a Master&#39;s degree in Cell and Gene Biotherapies, Yolande began her professional career as cell therapy engineer, focusing on the development of skin cell production protocols for clinical trials and associated controls. She joined the Centre d&#39;eXpertise Analytique (CXA) team in 2019, specializing in the development, validation and transfer of control methods for viral vectors gene therapy. She developed expertise in cell-based assay, flow cytometry and AUC. For the past year, she has been collaborating with SCIEX on implementing analytical methods for the control of rAAVs genome integrity using capillary electrophoresis.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Dr. Stephen Lock (Senior Market Development Manager, Biopharma at SCIEX)</p>
</blockquote>
<blockquote>
<p>Dr. Stephen Lock obtained his PhD in Physical Organic Chemistry from the University College of Swansea in 1993 and is a chartered chemist and a member of the Royal Society of Chemistry. Previously a lecturer of Chemistry at the University of Hull he has worked for SCIEX in various technical roles for over 25 years. He has over 30 years’ experience in Analytical Chemistry and has presented at nearly one hundred international meetings around the world. Steve is currently the EMEAI Biopharma Senior Market Development Manager for SCIEX and is also an Adjunct Professor at the University of Pannonia where he acts in a volunteer role as a Scientific Advisor for the Horváth Csaba Memorial Laboratory lead by Prof. Andras Guttman. At the Horváth Csaba Memorial Laboratory Steve provides technical advice and supports the groups fundamental research and development of new applications for capillary electrophoresis.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Juliette Laigle (Analytical Scientist at Yposkesi, an SK Pharmteco Company)</p>
</blockquote>
<blockquote>
<p>After obtaining her Master&#39;s degree in Pharmaceutical Biotechnology and Advanced Therapies, Juliette began her professional career as a Quality Control Engineer at Yposkesi, focusing on the validation of analytical methods used for viral vectors control. She then joined the Analytical eXpertise Center (CXA) team at its inception, specializing in the development, validation, and transfer of these methods, while also working on the implementation and automation of various analytical techniques. For the past year, she has been collaborating with SCIEX on implementing analytical methods for the control of rAAVs using capillary electrophoresis.</p>
</blockquote>


Technology Networks: Transforming Viral Vector Manufacturing With Capillary Electrophoresis

Transforming Viral Vector Manufacturing With Capillary Electrophoresis

In this webinar, our expert speakers will explore the different ways that CE is advancing biopharmaceutical development. 

Viral Vector Manufacturing With Capillary Electrophoresis

<h4><strong>Live from the Lab hosted by NIBRT: Solutions for biotherapeutic analysis</strong></h4>
<p><strong>By your side to accelerate your biopharmaceutical development journey</strong></p>
<p>Join us for the second Live from the Lab of 2024, taking place on September 17th, an exciting biopharma hybrid event featuring the latest advancements in separation technology and mass spectrometry. Focusing on all stages of biotherapeutics development, from discovery and research, all the way to routine and QC analysis, this event will give you valuable insights to accelerate your biopharmaceutical development journey.</p>
<p><strong>The following speakers will talk at this event at the NIBRT research facility which will be streamed live all over Europe:</strong></p>
<ul>
<li>Dr. Jonathan Bones, NIBRT</li>
<li>Prof. Mark Dickman, University of Sheffield</li>
<li>Dr. Dan Bach Kristensen, Symphogen</li>
<li>Dr. Mark Hilliard, Pfizer</li>
<li>Dr. Ken Cook, Thermo Fisher Scientific</li>
<li>Jon Bardsley, Thermo Fisher Scientific</li>
</ul>
<p>Whether you are a researcher, scientist, or industry professional in our region, this biopharma event is not to be missed. Expand your knowledge, network with experts, and discover how the Thermo Scientific solutions will stand by your side to accelerate your biopharmaceutical development journey.</p>
<p>Mark your calendars for September 17th and join us for this impactful hybrid event foster collaboration within the scientific community.</p>
<p>Participation is free of charge, registration is required.</p>
<p>For any questions about this event or regarding your registration, please email CMDEvents@thermofisher.com.</p>
<h4><strong>How to attend?</strong></h4>
<p><strong>3 ways of attending:</strong></p>
<h5><strong>Online attendees (remote):</strong></h5>
<p>Unable to travel to a satellite? Not a problem! You can register to attend conveniently online from your desk or anywhere else through the live stream from NIBRT.</p>
<ul>
<li><a href="https://assets.thermofisher.com/TFS-Assets/CMD/Flyers/fl-003119-pb-live-from-the-lab-ms-biotherapeutics-agenda-online-fl003119-em-en.pdf"><strong>Agenda</strong></a></li>
</ul>
<h5><strong>NIBRT Research Facility (in-person event):</strong></h5>
<p>Join the heart of the event where the main agenda will be hosted and live streamed across our region to our satellite events and our online audience. Attendance through VIP invitation only!</p>
<h5><strong>Join a ‘Satellite’ location (in-person event):</strong></h5>
<p>Across Europe, our in-person satellite events will be broadcasting the main agenda live streamed from NIBRT, Dublin and supplement the day with local speakers/lab tours pending on the satellite. Take this opportunity to network with fellow scientists and meet your Thermo Fisher representatives from technical, commercial, and service functions. Check out the closest location to you and their individual agenda!</p>
<ul>
<li><strong>Søborg, Denmark</strong> (AGC Biologics)</li>
<li><strong>Dreieich, Germany</strong> (Thermo Fisher Scientific)</li>
<li><strong>Segrate, Italy (MI)</strong> (Thermo Fisher Scientific S.P.A.)</li>
<li><strong>Leiden, Netherlands</strong> (Janssen Biologics BV)</li>
<li><strong>Ljubljana, Slovenia</strong> (Four Points by Sheraton Ljubljana Mons)</li>
<li><strong>Reinach, Switzerland</strong> (Thermo Fisher Scientific)</li>
<li><strong>Hemel Hempstead, UK</strong> (Thermo Fisher Scientific)</li>
</ul>


Thermo Fisher Scientific: Live from the Lab: Solutions for biotherapeutics

Live from the Lab: Solutions for biotherapeutics

An exciting biopharma hybrid event featuring the latest advancements in separation technology and mass spectrometry.

<p><strong>From developability assessment to commercial manufacturing, the development of biopharmaceutical drug products entails multiple characterization challenges, made all the more complex when considering the range of diverse molecular formats from proteins to advanced therapy medicinal products (ATMPs).</strong></p>
<p>Light scattering technologies provide key characterization tools that are key to addressing many of these challenges. Chief among these are multi-angle light scattering coupled to size-exclusion chromatography (SEC-MALS) and dynamic light scattering (DLS) performed without separation. Both techniques determine essential biophysical attributes in an absolute manner, rapidly and with no need for calibration against reference material or laborious sample preparation.</p>
<p>Following an introduction to light scattering technology and applications, this webinar will cover three case studies in the uses of SEC-MALS and DLS to characterize different types of biopharmaceuticals: antibodies, pegylated enzyme therapeutics and polyA-LNP. Attributes measured range from size and polydispersity, molar mass distribution and PEG-protein ratio to solution viscosity. These studies showcase the effectiveness of light scattering in supporting biopharmaceutical development towards successful commercialization.</p>
<p>Key Learning Objectives:</p>
<ul>
<li><p><strong>Strategies for assessing developability and optimizing drug formulations.</strong></p>
</li>
<li><p><strong>Technology and applications of light scattering for biopharmaceutical characterization.</strong></p>
</li>
<li><p><strong>Application of advanced analytical techniques (DLS, SEC-MALS) for biopharmaceutical characterization.</strong></p>
</li>
<li><p><strong>Addressing challenges specific to different biopharmaceutical molecule formats.</strong></p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Andrei Hutanu, Ph.D. (ten23 health)</p>
</blockquote>
<blockquote>
<p>Andrei Hutanu attended the Technical University of Munich from 2012-2018 where he got his degree in Biochemistry. He then started his Ph.D. at F. Hoffmann - La Roche Ltd with research focus on enhancing capillary electrophoresis (CE) methods for biopharmaceuticals. During his Ph.D., Andrei has established analytical methods for new modalities like mAb co-formulations and bispecific mAbs. In 2019, he switched his focus to method development for cell and gene therapy products with a special focus on recombinant adeno associated viruses. Since 2023, he is part of the analytical development team of ten23, a CDMO that aims to develop, manufacture, and test tomorrow’s medicines.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Michal M. Raczy, Ph.D. (ten23 health)</p>
</blockquote>
<blockquote>
<p>Dr. Michal M. Raczy is a Senior Scientist for Drug Product Design at ten23 health. Since joining the company in January 2022, he has led formulation and process development projects, while also driving innovation within biologics and surfactants analytics. With a strong background in chemistry and nanotechnology, Dr. Raczy obtained his PhD in molecular engineering from the University of Chicago (USA). During his doctoral studies, he conducted research on novel drug delivery systems and immunomodulatory biomaterials, leading to several published papers in prestigious peer-reviewed journals.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Daniel Some, Ph.D. (Waters | Wyatt Technology)</p>
</blockquote>
<blockquote>
<p>Dan Some leads product marketing for Wyatt’s process analytical and macromolecular interaction instrumentation. Prior to joining Wyatt he was involved in semiconductor and military electro-optics industries. Dan obtained his Ph.D in Physics from Brown University and carried out postdoctoral research at Los Alamos National Lab and Weizmann Institute of Science.</p>
</blockquote>


Waters Corporation: Developing Diverse Biopharmaceuticals with Light Scattering

Developing Diverse Biopharmaceuticals with Light Scattering

Strategies for assessing developability and optimizing drug formulations.

<p><strong>Fragmentation-based molecular annotations are the gold standard in high-confidence biomarker identification using mass spectrometry.</strong></p>
<p>The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach that allows spatial fragmentation and analysis of multiple targets in a single acquisition. The workflow includes a fully integrated pipeline within our software ecosystem to generate accurate identifications with spatial fidelity.</p>
<p>Key Learning Objectives:</p>
<ul>
<li><p><strong>Fragmentation based MALDI Imaging capabilities</strong></p>
</li>
<li><p><strong>iprm-PASEF workflow for the timsTOF fleX</strong></p>
</li>
<li><p><strong>Fragmentation based annotation pipeline using SCiLS™ Lab</strong></p>
</li>
</ul>
<p>Who should attend:</p>
<ul>
<li><p>Researchers interested in expanding their spatial biology toolkit</p>
</li>
<li><p>Researchers focused on maximizing confidence of molecular annotations for MALDI Imaging</p>
</li>
<li><p>Anyone who wants to expand their MALDI Imaging workflows</p>
</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Michael Becker, Ph.D. (Principal Scientist DMPK, Boehringer Ingelheim Pharma GmbH &amp; Co KG, Mainz, Germany)</p>
</blockquote>
<blockquote>
<p>Dr. Michael Becker is the head of the Mass Spectrometry Imaging lab at Boehringer Ingelheim. He received his Ph.D. in Neurobiology, and transitioned into the imaging field more than 15 years ago. He uses MSI to study drugs and drug-induced changes in tissue. To do so, he tries to push the sensitivity, reproducibility and specificity of the method.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Arne Behrens, Ph.D. (Application Specialist in MALDI Imaging, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)</p>
</blockquote>
<blockquote>
<p>Dr. Arne Behrens is an Imaging Applications Scientist  at Bruker in Bremen with more than 6 years of experience on the timsTOF fleX platform. He received his Ph.D. in Analytical Chemistry and is an expert for CCS-enabled MALDI Imaging applications.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Björn Wendik, Ph.D. (Business Development Manager, Bruker Daltonics GmbH &amp; Co. KG, Bremen, Germany)</p>
</blockquote>
<blockquote>
<p>Björn studied biology at the University of Würzburg and University of Freiburg with focus on developmental biology. In Freiburg he did his Ph.D. working on motoneuron development and pancreas formation. He became an expert on life cell imaging, timelapse studies and 3d-image software analyses. He continued his work as lecturer at the University of Freiburg where he also took care of parts of the Imaging core facility. When stepping into industry, he worked as a specialist for confocal microscopy and from there moved on into multispectral imaging, antibody based multi- and hiplexing and tissue analysis platforms. With this expertise, Björn started as a Business Development Manager for the MALDI Imaging at Bruker in July 2023.</p>
</blockquote>


Bruker: Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

Confidence in spatial identifications using iprm-PASEF on the timsTOF fleX

The new iprm-PASEF workflow integrates CCS-enabled MALDI Imaging of lipids with a targeted MS/MS imaging approach.

Confidence in spatial identifications using iprm-PASEF

<div class="summary-section section" style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);box-sizing:border-box;color:rgb(51, 51, 51);font-family:&quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin-bottom:34px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><h4 style="margin-left:0px;"><span style="font-family:-apple-system, BlinkMacSystemFont, &quot;Segoe UI&quot;, system-ui, &quot;Apple Color Emoji&quot;, &quot;Segoe UI Emoji&quot;, &quot;Segoe UI Web&quot;, sans-serif, &quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:18px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;white-space:pre-wrap;" name="summary" dir="ltr" id="isPasted"><strong style="box-sizing:border-box;" fr-original-style="">Session #2 - Innovative Approaches in HRMS and Software for PFAS Analysis</strong></span></span></h4><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong>We are excited to invite you to our upcoming webinar, where we will explore the latest advancements in PFAS analysis through innovative screening methods and technologies. Our expert speakers will cover various approaches to enhance the detection and identification of per- and polyfluoroalkyl substances (PFAS).</strong></span></p><h5 style="margin-left:0px;"><span style="font-size:18px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">1. Nontarget Screening workflow (NTS) for the Analysis of Per and Polyfluoroalkyl Substances (PFAS) using High resolution mass spectrometry (HRMS)</strong></span></span></h5><ul><li><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Presented by Hania Khoury-Hollins</strong></span></p></li></ul><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">This session will focus on using HRMS as an effective tool to detect both regulated and non-regulated PFAS. We’ll explore the UNIFI™ screening workflow and discuss the use of comprehensive PFAS libraries to improve detection capabilities.</span></p><h5 style="margin-left:0px;"><span style="font-size:18px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">2. Untargeted Screening for PFAS Chemicals Using Comprehensive Feature Detection</strong></span></span></h5><ul><li><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Presented by Jeff Goshawk</strong></span></p></li></ul><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">Discover how advanced feature detection methods can identify a wide range of PFAS chemicals, including those not covered by traditional reference standards. This talk will highlight techniques to detect novel PFAS-like chemicals, providing a broader understanding of total organic fluorine content in samples.</span></p><h5 style="margin-left:0px;"><span style="font-size:18px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">3. Elevating Specificity and Identification Confidence for PFAS Liquid Chromatography and Cyclic Ion Mobility Mass Spectrometry</strong></span></span></h5><ul><li><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Presented by Michael McCullagh</strong></span></p></li></ul><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">Learn how cyclic ion mobility (cIM) enhances the separation and identification of PFAS isomers. By using this method, we can achieve greater specificity and reduce analysis time, providing insights into PFAS exposure and its potential health impacts.</span></p><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">Join us to learn how these cutting-edge approaches are revolutionizing PFAS detection and analysis, offering more accurate and efficient solutions for environmental monitoring and public health protection.</span></p><div class="speaker-fields-container" style="box-sizing:border-box;padding-top:5px;"><div class="section" style="box-sizing:border-box;margin-bottom:34px;"><div class="sp-begin" style="box-sizing:border-box;clear:both;color:rgb(0, 0, 0);font-size:14px;"><blockquote><div style="box-sizing:border-box;"><span class="sp-name" style="box-sizing:border-box;"><strong>Presenter: </strong>Hania Khoury-Hollins (</span><span class="sp-title" style="box-sizing:border-box;">Principal Scientist, </span><span class="sp-company" style="box-sizing:border-box;">Waters Corporation)</span></div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;"><span class="sp-description" style="box-sizing:border-box;">Hania Khoury-Hollins is a scientist and researcher at Waters Corporation. She holds a bachelor’s degree in science, which laid the foundation for her scientific pursuits. In 2001, Hania earned her master’s degree in Toxicology, deepening her understanding of the impact of chemicals on living organisms. In 2005 she successfully defended her Ph.D. in physical chemistry from University René Descartes - Paris V (France). After undertaking several different projects in academia Hania spent some time working at Agilent before joining Waters.</span></div><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-description" style="box-sizing:border-box;">At Waters, her work revolves around developing cutting-edge analytical techniques and their applications with a focus on Liquid Chromatography coupled with High-Resolution Mass Spectrometry (LC-HRMS). Her expertise encompasses a diverse range of applications, including drug development, proteomics, metabolomics, and lipidomics. More recently, Hania has been developing applications strategies for per- and polyfluoroalkyl substances (PFAS).</span></p><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-name" style="box-sizing:border-box;"><strong>Presenter:&nbsp;</strong>Mike McCullagh (</span><span class="sp-title" style="box-sizing:border-box;">Consulting Scientist, </span><span class="sp-company" style="box-sizing:border-box;">Waters Corporation)</span></p><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-description" style="box-sizing:border-box;">Michael has worked at Waters Corporation for over 23 years. His main focus has been non-targeted analysis using time of flight mass spectrometry and ion mobility mass spectrometry. Michael has made contributions to various teams, including Food and Environmental, MS Evaluation, Life Science, Scientific Operations, the Advanced Mass Spectrometry Team and currently in Research, Development and Advanced Testing. Research has been performed across multiple application areas including, impurity profiling, pesticide screening, natural products, food analysis, metabolite identification and more recently non-targeted PFAS analysis. Having worn a number of different “hats”, the common thread has been the privileged opportunity to work with new technologies, new informatics solutions and to collaborate with industry and global collaborative partners, to forge a path to new discoveries and contribute to solutions to analytical challenges across multiple disciplines.</span></p><div style="box-sizing:border-box;"><span class="sp-name" style="box-sizing:border-box;"><strong>Presenter:&nbsp;</strong>Jeff Goshawk (</span><span class="sp-title" style="box-sizing:border-box;">Consulting Scientist, </span><span class="sp-company" style="box-sizing:border-box;">Waters Corporation)</span></div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;"><span class="sp-description" style="box-sizing:border-box;">Jeff is a Consulting Scientist at Waters Corporation and has been with the company for twenty-four years. Jeff started his career at Waters as a software developer working on MassLynx and its associated application managers. Jeff subsequently transitioned into the applications development group where he joined the toxicology team as a Principal Scientist. Jeff is now back in the software development world at Waters, and is currently working on the Pattern Analysis Application.</span></div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;"><span class="sp-name" style="box-sizing:border-box;"><strong>Presenter:&nbsp;</strong>Frank L. Dorman, PhD, FRSC (</span><span class="sp-title" style="box-sizing:border-box;">Principal Environmental Market Manager, </span><span class="sp-company" style="box-sizing:border-box;">Waters Corporation)</span></div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;"><span class="sp-description" style="box-sizing:border-box;">Frank Dorman is currently Senior Business Development Manager for Waters focusing on their global environmental business and, concurrently, Associate Professor (adjunct) in the Department of Biochemistry and Molecular Biology (BMB) at Penn State University in University Park, PA. In his role at Waters, Frank manages the research-focused environmental market, external collaborations and also interfaces with R&amp;D for new product development. Prior to Waters, Frank was employed full-time as a tenure-line Faculty member of Penn State and served as a member of the Graduate Faculty in: Biochemistry, Microbiology and Molecular Biology (BMMB), Chemistry (CHEM) and the Programs in Forensics Science (FRNSC), and Biogeochemistry (BGC). Frank is also a member of the Center for Molecular Toxicology and Carcinogenesis at Penn State. Frank’s scientific interests are in gas and liquid chromatography fundamental characterization, instrumentation and column development, as well and mass spectrometry and atomic spectroscopy as applied to trace analysis in complex sample matrices. This work is directed towards environmental forensics, traditional forensic chemistry and where environmental exposure events may contribute to human disease; an area sometimes referred to as “exposomics”.</span></div><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-description" style="box-sizing:border-box;">Prior to joining the faculty at PSU, Frank was at Restek Corporation for 14 years as the Director of Technical Development, and R&amp;D Senior Chemist. During most of this same time, Frank was also an Adjunct Research Professor at Juniata College where he maintained an active undergraduate research program. Prior to that he was at Inchcape Testing Services for 5 years as a Senior Chemist, Organics Section Manager for Sample Preparation and Corporate Methods Development Chemist. As such, Frank has extensive experience in both the Industrial and Academic sectors giving him a relatively rare combination of skills and experience.</span></p></blockquote></div></div></div></div>

Waters Corporation: Innovative Approaches in HRMS and Software for PFAS Analysis

Innovative Approaches in HRMS and Software for PFAS Analysis

Learn how these cutting-edge approaches are revolutionizing PFAS detection and analysis, offering more accurate and efficient solutions.

<div class="summary-section section" style="-webkit-text-stroke-width:0px;background-color:rgb(255, 255, 255);box-sizing:border-box;color:rgb(51, 51, 51);font-family:&quot;Segoe UI&quot;, Frutiger, &quot;Frutiger Linotype&quot;, &quot;Dejavu Sans&quot;, &quot;Helvetica Neue&quot;, Arial, sans-serif;font-size:14px;font-style:normal;font-variant-caps:normal;font-variant-ligatures:normal;font-weight:400;letter-spacing:normal;margin-bottom:34px;orphans:2;text-align:start;text-decoration-color:initial;text-decoration-style:initial;text-decoration-thickness:initial;text-indent:0px;text-transform:none;white-space:normal;widows:2;word-spacing:0px;"><p style="margin-left:0px;"><strong>This interactive session will bring together the MS community to discuss some of the most popular and exciting peer-reviewed publications in a friendly and open forum. Ahead of each meeting, we will send out a link to the discussion article, then during the session an expert will summarise the main findings and answer your questions.</strong></p><h5 style="margin-left:0px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Be prepared make sure you read&nbsp;</strong></span><a style="box-sizing:border-box;color:rgb(66, 139, 202);text-decoration:none;user-select:auto;" target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acscentsci.0c00049" fr-original-style=""><span style="color:#212121;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy</strong></span></span></a></h5><p style="box-sizing:border-box;margin:0px 0px 10px;" id="isPasted"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">We're going to </span><span style="font-size:14px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">be joine</span></span><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">d by Dr Rebecca Beveridge from the University of Strathclyde, a senior lecturer with a host of experience with development of native ion mobility mass spectrometry methods to study proteins and protein complexes&nbsp;</span></p><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary">This paper describes how Waters' SYNAPT MS can be utilized&nbsp;demonstrate the strength of native mass spectrometry to delineate the complex binding mechanisms of protein degraders, involving the formation of three-component protein−ligand complexes.</span></p><h5 style="margin-left:0px;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Reasons to Attend:</strong></span></h5><ul style="box-sizing:border-box;margin-bottom:10px;margin-top:0px;"><li style="box-sizing:border-box;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong>Debate some of the most topical papers from all-time favourites to some of the latest releases</strong></span><br>&nbsp;</li><li style="box-sizing:border-box;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong>Focus on understanding the benefit of SYNAPT MS and how to get the most out of the system for native mass spectrometry and biomolecule analysis</strong></span><br>&nbsp;</li><li style="box-sizing:border-box;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong>Gain a greater understanding of applications and technologies by asking questions of the authors and/or expert panel</strong></span><br>&nbsp;</li><li style="box-sizing:border-box;"><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong>No pre-recorded content, authors will be LIVE and on camera to answer questions</strong></span></li></ul><p style="box-sizing:border-box;margin:0px 0px 10px;" id="isPasted"><em style="box-sizing:border-box;"><i><span class="summary" style="box-sizing:border-box;overflow-wrap:break-word;" name="summary"><strong style="box-sizing:border-box;" fr-original-style="">Abstract&nbsp;</strong>Protein degraders, also known as proteolysis targeting chimeras (PROTACs), are bifunctional small molecules that promote cellular degradation of a protein of interest (POI). PROTACs act as molecular mediators, bringing an E3 ligase and a POI into proximity, thus promoting ubiquitination and degradation of the targeted POI. Despite their great promise as next-generation pharmaceutical drugs, the development of new PROTACs is challenged by the complexity of the system, which involves binary and ternary interactions between components. Here, we demonstrate the strength of native mass spectrometry (nMS), a label-free technique, to provide novel insight into PROTAC-mediated protein interactions. We show that nMS can monitor the formation of ternary E3-PROTAC-POI complexes and detect various intermediate species in a single experiment. A unique benefit of the method is its ability to reveal preferentially formed E3-PROTAC-POI combinations in competition experiments with multiple substrate proteins, thereby positioning it as an ideal high-throughput screening strategy during the development of new PROTACs</span></i></em></p><div style="box-sizing:border-box;clear:both;">&nbsp;</div><div class="speaker-fields-container" style="box-sizing:border-box;padding-top:5px;"><div class="section" style="box-sizing:border-box;margin-bottom:34px;"><div class="sp-begin" style="box-sizing:border-box;clear:both;color:rgb(0, 0, 0);font-size:14px;"><blockquote><div style="box-sizing:border-box;"><span class="sp-name" style="box-sizing:border-box;"><strong>Presenter: </strong>Dr Rebecca Beveridge (</span><span class="sp-title" style="box-sizing:border-box;">Senior Lecturer, </span><span class="sp-company" style="box-sizing:border-box;">University of Strathclyde)</span></div><div style="box-sizing:border-box;">&nbsp;</div><div style="box-sizing:border-box;"><span class="sp-description" style="box-sizing:border-box;">Rebecca is a Senior Lecturer and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020 as a Chancellor's Fellow. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.</span></div><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-description" style="box-sizing:border-box;">Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods.</span></p><p style="box-sizing:border-box;margin:0px 0px 10px;"><span class="sp-description" style="box-sizing:border-box;">Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.</span></p></blockquote></div></div></div></div>

Waters Corporation: Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy

Discuss some of the most popular and exciting peer-reviewed publications in a friendly and open forum.

Native Mass Spectrometry Can Effectively Predict PROTAC

<div class="summary-section section"><section class="section-padding"><div class="page-width"><div class="page-padding"><ul><li><strong>Reversed phase or normal phase?</strong></li><li><strong>Fully porous, partially porous, end capping?</strong></li></ul><p><strong>In this webinar we will cover different stationary phases (RP and NP) and the selection of the particle</strong>.</p><blockquote><p><strong>Presenter:</strong> Ceci<span class="sp-name">lia Mazza (</span><span class="sp-title">Product Specialist, EMEA IDO - Chemistries &amp; Suppliers, </span><span class="sp-company">Agilent)</span></p><p><span class="sp-description">With more than 20 years of professional experience, Cecilia is presently the Product Specialist for columns and supplies at Agilent. Supporting distributors and laboratory users in the analysis and purification of small and large molecules, for a wide range of LC and GC applications as well as sample preparation.</span></p><p><span class="sp-description">Cecilia holds a Ph.D. in Chemical Engineering from Rensselaer Polytechnic Institute in US.</span></p></blockquote></div></div></section></div>

Agilent Technologies: HPLC Beginner Webinar Series

Stationary Phases in HPLC - Part I

In this webinar we will cover different stationary phases (RP and NP) and the selection of the particle.

Ekotoxicita

Tentokrát Vás zavedeme do našich laboratoří v České Lípě a představíme Vám testy ekotoxicity.

Mohlo by Vás zajímat

25. Škola hmotnostní spektrometrie 2024 - finální program

Webinář ALS Czech Republic: Ekotoxicita

Agilent Microplastics Meeting 2024 (žive + online)