Nařízení (ES) č. 396/2005: stanovení reziduí pesticidů a kritická role koncentrování v metodě QuEChERS pro bezpečnost potravin

<p><strong>Zveme Vás na odborný seminář zaměřený na aktuální témata v oblasti bezpečnosti potravin, obalových materiálů a moderních analytických metod. Seminář se uskuteční ve čtvrtek 21. května od 10. hodin v SPACES Parkview, Pujmanové 1753/10a, 140 00 Praha 4.</strong></p><h3><strong>Registrace</strong></h3><blockquote><p class="cke-user_style-important"><strong>Registrujte se prosím e-mailem na: </strong><a href="mailto:Irena_Lofflerova@waters.com"><strong>Irena_Lofflerova@waters.com</strong></a></p><ul><li>Kapacita semináře je omezena.&nbsp;</li><li>Seminář je bezplatný.&nbsp;</li></ul></blockquote><h3><strong>Program</strong></h3><h5><strong>10:00 – 10:20 Zahájení semináře a úvod</strong></h5><ul><li>Waters</li></ul><h5><strong>10:20 – 10:50 Komplexní pohled na PFAS v bezpečnosti potravin: výskyt, zdroje a regulace</strong></h5><ul><li>Darina Dvořáková, VŠCHT Praha</li></ul><h5><strong>10:50 – 11:20 Analýza organických polutantů pomocí LC-MS v pitných a balených vodách</strong></h5><ul><li>Václav Šístek, ALS Czech Republic</li></ul><h5><strong>11:20 – 11:40 Kontaminanty v potravinách dle NAŘÍZENÍ KOMISE (EU) 2023/915 pohledem laboratoře VÚPS</strong></h5><ul><li>Marek Pernica, Výzkumný ústav pivovarský a sladařský Brno</li></ul><h5><strong>11:40 – 12:00 Kontrola jakosti medu</strong></h5><ul><li>Klára Bartáková, Veterinární univerzita Brno</li></ul><h5><strong>12:00 – 12:45 </strong>Přestávka na občerstvení a diskusi</h5><h5><strong>12:45 – 13:05 Výzvy a troubleshooting v LC–MS/MS a přípravě vzorků tučných potravin pro stopovou analýzu obalových kontaminantů</strong></h5><ul><li>Adam Vavrouš, Státní zdravotní ústav</li></ul><h5><strong>13:05 – 13:25 Od legislativních požadavků k laboratorní praxi: LC-MS/MS jako nástroj kontroly krmiv</strong></h5><ul><li>Libor Jaša, ÚKZÚZ Brno</li></ul><h5><strong>13:25 – 13:45 Aplikace NMR metabolomiky v hodnocení kvality a autenticity potravin</strong></h5><ul><li>Jaroslav Havlík, Česká zemědělská univerzita v Praze</li></ul><h5><strong>13:45 Ukončení semináře</strong></h5><p><strong>Těšíme se na Vaši účast!</strong></p>

Pozvánka na Waters Seminář FOOD & Water

<p><strong>Metformin je v současnosti základním perorálním lékem první volby pro léčbu diabetu 2. typu. Snižuje tvorbu glukózy v játrech, zlepšuje citlivost tkání k inzulinu a nevede k přibývání na váze ani k hypoglykemiím, což jej odlišuje od některých jiných antidiabetik. Navíc je u něj prokázaný dlouhodobý příznivý vliv na riziko kardiovaskulárních komplikací a úmrtnosti u pacientů s diabetem 2. typu. Vědci z Fyziologického ústavu AV ČR identifikovali novou skupinu krevních metabolitů, která může lékařům pomoci objektivně sledovat, zda pacienti s diabetem 2. typu opravdu užívají lék metformin tak, jak mají.</strong></p><h4>​<strong>Nové biomarkery při užívání metforminu</strong></h4><p>Tým vedený Tomášem Čajkou z Oddělení translačního metabolismu Fyziologického ústavu AV ČR analyzoval pomocí <strong>pokročilé metabolomiky a lipidomiky</strong> plazmu 637 pacientů s diabetem 2. typu léčených metforminem a 143 nediabetických kontrol. V souboru 614 metabolitů se jim podařilo odhalit <strong>pět metabolitů ze skupiny N-laktoyl aminokyselin</strong> (např. N‑laktoyl fenylalanin), které byly dříve detekovány jako neznámé signály, jelikož v referenčních databázích chyběla jejich spektra. Hladiny těchto metabolitů v krvi velmi dobře kopírovaly množství metforminu v plazmě. U pacientů s <strong>nejvyšší expozicí metforminu</strong> byly <strong>koncentrace těchto metabolitů až 7,2× vyšší než u kontrol.</strong></p><h4>​<strong>Citlivý „otisk“ účinku léku</strong></h4><p><strong>N‑Laktoyl aminokyseliny</strong> vznikají v buňkách spojením laktátu a aminokyselin a odrážejí tak metforminem navozené změny v buněčném energetickém metabolismu. „<i>Zásadní je, že i když se v plazmě vyskytují jen v nanomolárních koncentracích, dokážou spolehlivě odlišit pacienty, kteří metformin užívají pravidelně, od těch, kteří ho berou nepravidelně nebo vůbec</i>“, zdůrazňuje T. Čajka.</p><blockquote><p>Rozhovor s doc. Tomášem Čajkou můžete zhlédnout <a target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/reel/1657952168601400"><strong>ZDE</strong></a></p></blockquote><h4><strong>Metabolomika v praxi a mezinárodní spolupráce</strong></h4><p>Studie přináší také detailní popis širších metabolických změn u diabetu 2. typu, včetně zvýšení laktátu, organických kyselin a rozvětvených aminokyselin a rozsáhlého přestavění lipidového profilu. Na práci, publikované v časopise <i><strong>Clinical Pharmacology &amp; Therapeutics</strong></i>, se kromě týmu T. Čajky podíleli i partneři z <strong>Institutu klinické a experimentální medicíny v Praze</strong> a <strong>West Coast Metabolomics Center</strong> (University of California, Davis). Výsledky ukazují, že moderní metabolomické přístupy vyvinuté ve Fyziologickém ústavu AV ČR v rámci<strong> projektu CarDia</strong> mohou najít velmi praktické uplatnění v klinických studiích i v individuálním sledování léčby pacientů s diabetem.</p><blockquote><h4><strong>Původní článek</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70205"><strong>Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes</strong></a></h4><p>Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik</p><p>Clin Pharmacol Ther, 119: 1057-1069</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/cpt.70205">https://doi.org/10.1002/cpt.70205</a></p><h6>licencováno pod <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstrakt</strong></h4><p>Metformin je nejčastěji předepisovaným antidiabetikem, přesto zůstává objektivní hodnocení adherence pacientů k léčbě obtížné. Pomocí necílené metabolomiky a lipidomiky jsme analyzovali plazmu od 637 pacientů s diabetem 2. typu (T2D) s potvrzeným užíváním metforminu a od 143 nediabetických kontrol, přičemž bylo anotováno 614 metabolitů. Pacienti byli rozděleni podle plazmatické koncentrace metforminu do skupin se subterapeutickými, terapeutickými a supraterapeutickými hladinami a asociace byly hodnoceny pomocí vícenásobné lineární regrese a kompozitního hodnocení metabolitů. Pět dosud neanotovaných signálů bylo strukturně identifikováno jako N-laktoyl-aminokyseliny, jejichž hladiny silně korelovaly s plazmatickou koncentrací metforminu (ρ = 0,42–0,55, P &lt; 0,0001) a ve skupině se supraterapeutickými koncentracemi (&gt; 2000 ng/mL) vzrostly až 7,2násobně. Přestože byly N-laktoyl-aminokyseliny konzistentně detekovány v nanomolárních koncentracích, vykazovaly robustní a na dávce závislé asociace s metforminem. Širší metabolické změny u T2D zahrnovaly zvýšené hladiny laktátu, organických kyselin a aminokyselin s rozvětveným řetězcem spolu se sníženými hladinami metabolitů močovinového cyklu. Lipidomická analýza ukázala zvýšení nasycených triacylglycerolů a diacylglycerolů a naopak snížení esterů cholesterolu, sfingomyelinů a fosfolipidů. Tyto výsledky potvrzují N-laktoyl-aminokyseliny jako robustní plazmatické biomarkery expozice metforminu s odpovědí závislou na dávce. Přestože jsou až o čtyři řády méně zastoupené než jejich aminokyselinové prekurzory, citlivě odrážejí mitochondriální nadprodukci laktátu a farmakodynamickou adaptaci, což umožňuje objektivní hodnocení adherence k léčbě.</p>

Nové krevní biomarkery odhalují, jak poctivě pacienti s diabetem užívají lék metformin

Potraviny

Vody

Zdraví

Vědecký článek

Věda a výzkum

Článek

Laboratoře

Produkt

Nejbližší akce

Akademie věd České republiky (AV ČR) vznikla v roce 1992 jako nástupce někdejší Československé akademie věd. V současnosti ji tvoří komplex 54 veřejných výzkumných institucí.

Akademie věd České republiky

Společnost Organomation, založená v roce 1959, navrhuje a vyrábí vysoce kvalitní dusíkové koncentrátory a extrakční systémy. Jejich laboratorní přístroje, známé svou inovativností a odolností, se používají po celém světě pro efektivní přípravu vzorků a jsou doprovázeny silnou zákaznickou podporou.

Organomation

Firmu Waters založil v roce 1958 pan James Waters. Od té doby se společnost Waters specializuje na kapalinovou chromatografii a hmotnostní spektrometrii. Divize TA Instruments působí na poli termální analýzy. V České republice je Waters zastoupen přímou pobočkou, která sídlí v Praze.

Waters Gesellschaft

Agilent Technologies

Technology Networks

Milestone

Thermo Fisher Scientific

Altium International (HPST)

SelectScience

Waters Corporation

<h4><strong>Food &amp; Feed Sample Preparation Webinar Series</strong></h4><p><strong>Ensuring food and feed quality requires reliable determination of both contaminants and nutrients, yet sample preparation remains one of the most challenging and time-consuming steps in the analytical workflow. This webinar series introduces modern approaches to digestion and extraction that improve data quality, reduce reprocessing, and increase laboratory productivity. Through four dedicated events, covering heavy metals, organic contaminants, macro/trace minerals, and nutritional parameters such as fats, FAMEs, and amino acids, participants will discover optimized, practical workflows tailored to real-world food and feed testing.</strong></p><h4><strong>Session: Modern Sample Prep for Organic Contaminants: PAHs, PFAS, MOSH/MOAH in Food</strong></h4><p>Organic contaminants in food, such as PAHs, PFAS, and MOSH/MOAH, require extraction workflows that are efficient, reproducible, and compliant with regulatory methods. This webinar showcases microwave-assisted extraction using microwave technologies to streamline sample preparation while reducing solvent use and improving recoveries. We will discuss best practices for preventing contamination, handling lipid-rich matrices, and managing PFAS-specific requirements. Attendees will learn how advanced extraction technology supports reliable quantification of these high-profile contaminants across diverse food products.</p><blockquote><p><strong>Speaker:</strong> Luca Rota (Application Specialist, Milestone Srl)</p></blockquote>

Milestone: Food & Feed Sample Preparation Webinar Series

Modern Sample Prep for Organic Contaminants: PAHs, PFAS, MOSH/MOAH in Food

Modern sample preparation for PAHs, PFAS, and MOSH/MOAH in food using microwave extraction to improve efficiency, compliance, and data quality.

Modern Sample Prep for PAHs, PFAS, MOSH/MOAH in Food

<h3><strong>A five-part webinar series unlocking advanced insights across the Peptide therapeutics workflows</strong></h3><p><strong>Peptide therapeutics are reshaping modern medicine, with GLP-1 receptor agonists driving rapid advances in metabolic disease treatment. As peptide and GLP-1 programs scale, scientists face increasing pressure to generate data that is accurate, defensible, and decision-ready across development stages.</strong></p><p>Peptide 360 is designed to guide scientists through this complexity, following the peptide workflow from sequence insight to confident development decisions.</p><h5><strong>Who Should Attend?</strong></h5><p>This series is designed for scientists and technical leaders working in peptide and GLP-1 discovery and development, analytical development, characterization, Bioanalysis, DMPK, translational research, CMC, QA/QC, and regulatory-facing analytical roles</p><h5><strong>How the Series Works?</strong></h5><ul><li>Register once for the full series</li><li>Pre-submit questions for live expert responses</li><li>Access recordings anytime after each session</li><li>Certificate of attendance provided</li></ul><h4><strong>Episode 4: Accelerating LC/MS Impurity Screening Followed by ECD-Based Sequence Analysis for GLP-1 Analogs</strong></h4><p>As GLP-1 analogs increase in structural complexity, efficient impurity profiling requires both speed and structural clarity. This session presents a staged LC/MS-based workflow that enables rapid impurity screening to identify candidates requiring deeper investigation, followed by targeted ECD-based sequence analysis for detailed structural insight. By separating fit-for-purpose screening from high-resolution characterization, the workflow reduces unnecessary analytical complexity and shortens the path from detection to interpretation.</p><p>Attendees will learn how electron capture dissociation (ECD) preserves labile modifications, enabling precise localization and confident sequence confirmation. The session highlights how tiered impurity strategies support timely, data-driven decisions during GLP-1 development.</p><blockquote><p><strong>Presenter: </strong>Rachel Franklin (Application Development Scientist, Agilent Technologies, Inc.)</p><p><strong>Presenter:&nbsp;</strong>Ashish Pargaonkar, Ph.D. (Biopharma Applications Specialist, Agilent Technologies, Inc.)</p></blockquote>

Agilent Technologies: Peptide 360: Mastering the Invisible from Sequence to Confidence

Accelerating LC/MS Impurity Screening Followed by ECD-Based Sequence Analysis for GLP-1 Analogs

Peptide 360 Episode 4 webinar on LC/MS impurity screening and ECD sequence analysis for GLP-1 analog characterization.

Accelerating LC/MS Impurity Screening for GLP-1 Analogs

<p><strong>Retence polárních analytů v podmínkách vysokého podílu vodné složky mobilní fáze v reverzně-fázové chromatografii (RP-LC) zůstává dlouhodobou výzvou při vývoji analytických metod. Kolony Agilent Poroshell Aq-C18, využívající technologii povrchově porézních částic, umožňují stabilní provoz i při 100% vodné mobilní fázi bez kolapsu stacionární fáze. Díky své univerzálnosti napříč širokým spektrem aplikací jsou tyto kolony obzvláště vhodné pro farmaceutickou analýzu, mimo jiné i díky svému zařazení v USP.</strong></p><blockquote><p><strong>Přednášející:</strong> Giorgio Ferlat (EMEAI IDO (International Distributor Organization) Product Specialist Chemistries and Supplies Agilent Technologies)</p><p>Giorgio has more than 20 years of experience in Chromatography Columns troubleshooting, sales and business development. He covered various international positions and at present is Agilent Product Specialist EMEAI-IDO, and responsible for developing the Agilent Chemistries and Supplies business in the indirect sales channels of Central Eastern Europe, Africa and the Middle East.</p></blockquote>

Altium: Pokročilá retence a rozlišení polárních analytů s využitím kolon Agilent Poroshell Aq-C18 s povrchově porézními částicemi

Pokročilá retence a rozlišení polárních analytů s využitím kolon Agilent Poroshell Aq-C18 s povrchově porézními částicemi

Agilent Poroshell Aq-C18 umožňují stabilní RP-LC při 100% vodné mobilní fázi a lepší retenci polárních analytů.

Stabilní RP-LC polárních analytů s Agilent Poroshell Aq-C18

<p><strong>Microplastics are increasingly detected across the environment and even within the human body, raising urgent questions about their sources, exposure pathways, and health implications.</strong></p><p>In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.</p><p>Discover how<strong> FTIR and Raman spectroscopy</strong> enable reliable particle identification and imaging—covering sizes from millimeters down to a few microns—while high-resolution mass spectrometry techniques such as pyrolysis <strong>GC-HRMS and LC-based workflows</strong> provide sensitive detection and quantification of polymers and plastic-related chemicals in complex environmental and biological matrices.</p><p>From particle-level identification to advanced chemical fingerprinting and exposure assessment, learn how Thermo Fisher Scientific technologies support micro- and nanoplastics analysis across research, environmental monitoring, and human biomonitoring applications.</p><blockquote><p><strong>Speaker: </strong>Dr. Kuanliang Shao (Postdoctoral Fellow, Department of Environmental Health Comprehensive Laboratory for Untargeted Exposome Science | Emory University) will share how Py-GC-HRMS is enabling population-level biomonitoring of MNPs in human tissues and its integration into exposomics frameworks.</p><p><strong>Speaker:&nbsp;</strong>Dr. Wang Rui (Business Development Manager, Chemical Analysis | Thermo Fisher Scientific) will provide an overview of FTIR and Raman spectroscopy solutions for microplastics identification, highlighting how technologies ranging from point-and-shoot systems to advanced imaging platforms enable reliable analysis across diverse environmental samples and particle sizes, from millimeters down to a few microns.</p></blockquote>

Thermo Fisher Scientific: Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

Uncovering Microplastics: Identification, Quantification, and Exposure Assessment

In this webinar, we will explore complementary analytical solutions for comprehensive microplastics characterization.

Microplastics Identification, Quantification

<h4><strong>Advanced Size Variant Analysis of Antibodies and ADCs Using SEC Techniques</strong></h4><p><strong>Size‑exclusion chromatography (SEC) is essential for analyzing aggregates, monomers, and fragments in biotherapeutic proteins, but traditional methods often require extensive optimization due to non‑desired ionic and hydrophobic interactions. Learn how these innovations improve resolution, reduce eluent complexity, support SEC-MALS, SEC-MS, 2D Protein A -,SEC workflows, and deliver robust, out-of-the-box performance across a wide range of protein modalities.</strong></p><ul><li>Review SEC fundamentals and smart column selection</li><li>Build robust, platform-ready SEC methods for mAbs</li><li>Leverage advanced MALS and MS detectors for deeper insight</li><li>Direct analysis of mAb HMWS in cell-culture with 2D Protein A- SEC</li></ul><p>This webinar is designed for Scientists in Biopharma, CXOs, Academic, Government performing SEC-based protein separations.</p><blockquote><p><strong>Speaker: </strong>Stephan M. Koza, Ph.D. (Senior Principal Scientist, Waters Corporation)</p><p>Stephan Koza has worked at Waters Corporation for over 10 years and has a primary focus on the use of LC, LC-MS, and sample preparation chemistries and columns for the analysis of biomolecules.</p><p>Prior to joining Waters, he had nearly twenty years of experience with biopharmaceutical characterization and analytical method development with Genetics Institute, Wyeth, and Pfizer.</p><p>Stephan received his doctorate in analytical chemistry at the University of New Hampshire.</p><p><strong>Speaker:&nbsp;</strong>Bill Warren (Principal Consultant Product Manager, Waters Corporation)</p><p>Bill joined Waters in 1986 as a senior applications chemist involved with the research and development of HPLC, FPLC, and Capillary Electrophoresis applications for the analysis and purification of proteins, peptides, and nucleic acids.</p><p>Bill currently is a Principal Consultant Product Manager whose responsibilities involve assisting in the development and commercialization of innovative reagents and chromatography-based technologies for the separation, purification, and characterization of biological molecules</p><p><strong>Speaker:&nbsp;</strong>Udayabagya (Bud) Halim (Sr. Product Marketing Analyst, Waters Corporation)</p><p>Bud Halimis a senior marketing analyst at Waters | Wyatt Technology with a PhD in physical chemistry from UCLA.</p><p>He began his career teaching biochemistry and chemistry and contributing to laboratory manuals before transitioning into the scientific instrumentation industry as an applications scientist.</p><p>At Waters, he supports researchers in the characterization of peptides, biologics, lipid nanoparticles (LNPs), and viral vectors.</p></blockquote>

Size variant analysis of antibodies and ADCs using SEC, SEC-MALS, SEC-MS, and 2D Protein A-SEC Methods

Review SEC fundamentals and smart column selection

Size variant analysis of antibodies and ADCs

<p><strong>As demand for glucagon-like peptide-1 (GLP-1) therapies continues to rise, ensuring they meet strict regulatory standards while delivering fast, reliable results is more important than ever. Traditional amino acid analysis (AAA) workflows provide valuable quantitative insight into bioprocess conditions but can be time-intensive and operationally complex.</strong></p><p>In this SelectScience® webinar, biologic drug screening and protein analysis experts, Dr. Duanduan Han and Dr. Tim Anderson will present a microwave-assisted UPLC approach that accelerates hydrolysis, labeling, and identification of GLP-1 analogs using the Waters AccQ·Tag Ultra Chemistry Kit. They will also discuss how this approach simplifies amino acid analysis to significantly reduce turnaround time, whilst maintaining accuracy and reproducibility.</p><p>Plus, they will share how this microwave-assisted UPLC approach can be seamlessly integrated into an Empower™ Chromatography Data System (CDS) workflow to support efficient data processing and compliance.</p><p>Register today to learn how to enhance productivity, improve consistency, and meet the growing demands of GLP-1 development and manufacturing.</p><h5><strong>Certificate of attendance</strong></h5><ul><li>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.&nbsp;</li><li>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><blockquote><p><strong>Speaker: </strong>Dr. Duanduan Han (Senior Scientist, Waters Corporation)</p><p>Dr. Duanduan Han received her Ph.D. in chemical engineering from Texas A&amp;M University, and now works as a Senior Scientist at Waters Corporation in Milford, Massachusetts. Dr. Han's work has focused on LC/MS method development and troubleshooting, impurity profiling, raw material screening of GLP-1s, lipid nanoparticles, surfactants, oligonucleotides, mAbs, and other biologic drug products.</p><p><strong>Speaker:&nbsp;</strong>Dr. Tim Anderson (Senior Product Manager, Waters Corporation)</p><p>Dr. Tim Anderson has received advanced degrees in Analytical Chemistry and Food Science related to extraction and MS analysis of proteins at Iowa State University. He has industry experience with large manufacturing product analysis and fit-for-use testing. He has been at Waters working with consumables for 3 years and is Senior Product Manager for AccQ·Tag Ultra solutions.</p><p><strong>Speaker:&nbsp;</strong>Olivia Long (Editorial Team, SelectScience)</p><p>As a Science Editor specializing in pharmaceutical and applied research, Olivia Long brings a strong background in experimental biology and scientific communication. She holds a B.Sc. in Pharmacology from the University of Southampton and an M.Sc. in Neuroscience from the University of Sussex, where she investigated neuro‑oncology drug‑resistance pathways using patient‑derived cell models.</p><p>Her broader laboratory experience spans R&amp;D hygiene testing, controlled environment entomology workflows, and protocol development, giving her a practical understanding of diverse analytical and research environments. She is dedicated to translating complex science into clear, engaging content for researchers and industry professionals.&nbsp;</p></blockquote>

Select Science: Achieve faster GLP-1 amino acid analysis with rapid UPLC technology

Achieve faster GLP-1 amino acid analysis with rapid UPLC technology

Rapid GLP-1 amino acid analysis using UPLC. Boost drug development productivity with microwave hydrolysis and automated workflows.

GLP-1 amino acid analysis with rapid UPLC

<h4><strong>Bringing laboratory automation to life with Andrew+ and OneLab</strong></h4><p><strong>This webinar series explores how Andrew+ automated liquid handling and OneLab workflow software support consistent, traceable and efficient laboratory operations. Through application‑focused episodes, you will see how automation can be successfully integrated into everyday laboratory workflows, from method development to routine and regulated environments, supported by real‑world customer experiences and testimonials.</strong></p><h4><strong>Episode 2 – Biomolecules Workflows</strong></h4><p>Biomolecule workflows often involve complex and labour-intensive sample preparation steps. This episode demonstrates how automation can simplify challenging protocols while maintaining the flexibility required for method development and routine analysis, illustrated through customer examples and practical feedback.</p><h4><strong>Key highlights</strong></h4><ul><li>Automate demanding biomolecule workflows, including therapeutic oligonucleotides and peptides</li><li>Simplify complex steps such as serial dilutions and liquid–liquid extraction</li><li>Improve traceability and data integrity through structured workflow execution</li></ul><blockquote><p><strong>Speaker: </strong>Philip Quinn (Senior Applications Specialist Chemistry Europe - Waters Corporation)</p><p>Phil started his career at Waters in 2018 as an Application Support Specialist in the Chemistry Consumables group for the UK. In his current role he is responsible for commercial pre and post-sale support for Chemistry Consumables and Automation across Europe. Prior to joining Waters, Phil worked at large Pharma organisations over 10+ years and gained extensive experience in Analytical Development and QC environments, including the Development, Optimisation, Validation and Transfer of LC methodologies</p><p><strong>Customer Testimonials: </strong>OligoTune Ltd.</p><p>OligoTune Ltd. is a biotechnology company developing RNA oligonucleotide therapeutics for oncology applications.<br>In this webinar episode, OligoTune shares an end‑user perspective on biomolecule sample preparation, highlighting the challenges of handling therapeutic oligonucleotides in an R&amp;D environment. The discussion demonstrates how automated workflows can support consistency, efficiency and traceability during biomolecule method development.</p></blockquote>

Transform Your Daily Lab Operations with Automation - Biomolecules Workflows

Automate biomolecule workflows with Andrew+ and OneLab. Improve traceability, efficiency, and consistency in oligonucleotide and peptide analysis.

Transform Your Daily Lab Operations with Automation

<h4><strong>Join us to see how CDMS extends the reach of mass spectrometry - turning molecular complexity into actionable insight.</strong></h4><p><strong>As biomolecular systems grow larger and more heterogeneous, conventional MS reaches its limits. Charge detection mass spectrometry (CDMS) overcomes these challenges by directly measuring the mass of individual ions. In this webinar, two experts show how CDMS enables accurate characterization of complex systems in biopharma and structural virology. Dr. Andi Flütsch (Johnson &amp; Johnson) examines heterogeneous glycoprotein vaccines, while Prof. Charlotte Uetrecht (University of Lübeck, CSSB) reveals viral capsid heterogeneity and assembly using norovirus.</strong></p><h4><strong>Why you should attend</strong></h4><ul><li>Understand why CDMS matters for analyzing highly heterogeneous, high mass biomolecules beyond the limits of conventional native MS.</li><li>See how CDMS solves real biopharma challenges, enabling characterization and comparability of complex glycoprotein vaccines where traditional analytics fall short.</li><li>Gain new insight into viral heterogeneity, learning how CDMS reveals mass, stoichiometry, and assembly features inaccessible with native MS alone.</li></ul><h4><strong>Who should attend</strong></h4><ul><li>Scientists and engineers working with complex molecular or particulate systems across chemistry, biology, biopharma, materials, and nanoscience</li><li>Analytical and structural science leaders looking to push beyond the limits of conventional mass spectrometry for heterogeneous, high mass samples</li><li>R&amp;D managers and decision makers evaluating next generation analytical technologies to enable deeper insight and more confident decisions</li></ul><blockquote><p><strong>Speaker: </strong>Charlotte Uetrecht (Professor/Scientific Director, University of Lübeck/Centre for Structural System Biology (CSSB))</p><p>Professor Charlotte Uetrecht has been Full Professor of Chemistry at the University of Lübeck since 2024, co director of the Institute of Chemistry and Metabolomics, and Scientific Director of the Centre for Structural Systems Biology (CSSB) since 2026. She leads the Dynamics of Viral Structures group, focusing on large viral protein complexes using native mass spectrometry and complementary structural methods, with emphasis on coronaviruses and norovirus particles. She earned her Ph.D. from Utrecht University under Prof. Albert J.R. Heck.</p><p><strong>Speaker:&nbsp;</strong>Andi Flütsch (Associate Director, Analytical &amp; Process Development, Johnson &amp; Johnson Innovative Medicine)</p><p>Dr. Flütsch is an Associate Director in Analytical &amp; Process Development at Johnson &amp; Johnson Innovative Medicine based in Switzerland. He has extensive experience in analytical development and protein characterization, supporting products from late-stage development through commercialization. His work focuses on advanced analytical technologies and GMP‑ready analytical strategies for complex modalities such as glycoproteins and viral vectors. Dr. Flütsch received Ph.D. from University of Zurich in 2013 in Biochemistry and Molecular Biology.</p></blockquote>

CDMS Applied: Bridging Molecular Complexity and Clarity from Bioconjugates to Viruses

CDMS enables analysis of complex biomolecules beyond native MS. Discover applications in glycoprotein vaccines and viral structure characterization.

CDMS: From Bioconjugates to Viral Complexity

<h4><strong>Resolve your separation challenges</strong></h4><p><strong>Biphenyl stationary phases are increasingly used to resolve separations that challenge conventional C18 and phenyl chemistries, particularly for aromatic analytes and positional isomers. However, traditional biphenyl columns can suffer from elevated UV-detected bleed, limited pH stability, and inconsistent batch performance.</strong></p><p>This presentation shows how a trifunctionally bonded biphenyl phase on a hybrid ethylene-bridged particle delivers balanced hydrophobic and aromatic selectivity with stable performance from pH 1.5–10 and ≥10× lower UV bleed. Inert column hardware further improves recovery of metal-sensitive analytes. Pharmaceutical, bioanalytical, and food/environmental examples demonstrate robust, reproducible separations.</p><h4><strong>What you will learn</strong></h4><ul><li>Recognize limitations of traditional biphenyl phases affecting robustness and quantitation.</li><li>Explain trifunctional biphenyl design enabling balanced selectivity, wide pH stability.</li><li>Apply biphenyl selectivity and inert hardware to improve recovery.</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for you if you are a Pharma Method Developer, R&amp;D Method Developer, or Bioanalytical Scientist looking to optimize and future proof your analytical methods.</p><blockquote><p><strong>Speaker: </strong>Chris Collins, Ph.D. (Principal Product Marketing Manager, Waters Corporation)</p><p>Chris Collins, Ph.D. earned his Ph.D. in Analytical Chemistry from North Carolina State University in 2014. He has over 20 years experience in the pharmaceutical industry with a focus on LC/MS Method Development.</p><p>Chris started working at Waters Corporationin2018 as a Chemistry Account Manager for North Carolina/South Carolina. In 2023, he transitioned to the role of Principal Product Marketing Manager for ACQUITY UPLC columns and MaxPeak Premier Column Technology.</p></blockquote>

Beyond C18 and Phenyl: Expanding Selectivity with Biphenyl Columns Built for UV and pH Robustness

Learn how advanced biphenyl LC columns improve selectivity, pH stability, UV bleed, and recovery for pharmaceutical, bioanalytical, and environmental analyses.

Expanding Selectivity with Biphenyl Columns

<p><strong>Early analytical choices in monoclonal antibody development can influence how programs progress through validation, technology transfer, and later-stage scale up and development. &nbsp;</strong></p><p>This webinar explores how decisions made during the investigational new drug (IND) stage can impact validation readiness, technology transfer, and regulatory success. Focusing on molecular characterization, residual DNA control, and microbial contamination risk, it highlights common gaps that can emerge as programs advance.</p><p>Attendees will learn practical approaches on designing analytical strategies that are robust, adaptable, and fit for purpose across the different stages of development, helping reduce rework and support long term development success.</p><h4><strong>Attend this webinar to:</strong></h4><ul><li>Analyze common lifecycle vulnerabilities in IND-stage analytical strategies</li><li>Evaluate whether early titer methodologies are structured for validation and technology transfer</li><li>Assess residual DNA testing approaches for regulatory defensibility and scalability</li><li>Determine how microbial control and identification frameworks should adapt as programs advance&nbsp;</li></ul><blockquote><p><strong>Speaker:&nbsp;</strong>Sandi True, PhD (Staff Scientist, Field Applications, Thermo Fisher Scientific)</p><p>Sandi completed her PhD at the University of Nebraska Medical Center and Eppley Institute for Cancer Research focusing on RNA viruses. She has made a career in field applications after completing postgraduate training in laboratories with the Environmental Protection Agency and the FBI.</p></blockquote>

Thermo Fisher Scientific: Building Analytical Strategies for Scalable Antibody Development

Building Analytical Strategies for Scalable Antibody Development

How decisions made during the investigational new drug stage can impact validation readiness, technology transfer, and regulatory success. 

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