Leveraging prm-PASEF on the timsTOF Pro to Interrogate the Functional Proteome
Integrated TIMS with PASEF affords an opportunity for highly selective, rapid detection and reproducible quantification of peptides in complex matrices. This platform is ideally suited for functional protein profiling.
PRM-LIVE accounts for potential retention time drift of peptides across multiple LC analyses
PRM-LIVE provides for reproducible quantification of nearly 2,000 peptides in complex cellular proteomes
PRM-LIVE provides a powerful platform for profiling the binding behavior of selective small molecule inhibitors
Presenter: Jarrod A. Marto, Ph.D. (Associate Professor, Dept. of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Dana-Farber Cancer Institute)
Dr. Marto received his Ph.D. in analytical chemistry at The Ohio State University with Alan Marshall and went on to postdoctoral studies at the University of Virginia with Don Hunt. After several years in the biotech sector, Dr. Marto joined the Dana-Farber Cancer Institute in 2004. Dr. Marto uses mass spectrometry as a primary discovery tool to understand how genomic alterations, environmental insults, or the action of small molecule chemical probes impact the functional proteome, including protein post-translational modifications, biochemical complexes, signaling pathways, or how they manifest en masse as phenotypic or disease signatures. Dr. Marto’s research is further enabled by development of advanced chromatographic separation platforms which provide improved peptide detection and quantification, and support genome-scale interrogation of mammalian proteomes. In addition, his lab builds open-source computation tools that facilitate interrogation of mass spectrometry data across the full spectrum of scientific inquiry, from the underlying instrumentation to interpretation of quantitative proteomic data in the context of biological pathways. His research program represents a productive convergence of biology, computation, and analytical science.
Moderator: Dr. Martin Graf-Utzmann (Wiley Analytical Science, Lab Automation & Equipment)
Dr. MartinGraf-Utzmann studied Chemistry at the FAU Erlangen-Nuremberg, worked on his PhD. Thesis at the Max-Planck-Institute for Coal Research in Mülheim an der Ruhr. Since 2008 he works for Wiley, starting in the books editorial team and since2013 in the B2B group.
