BioSPME: A new tool for drug-protein binding determination
The use of solid-phase microextraction (SPME) has been widely accepted as a fast and convenient sample preparation method. It has been applied to a wide range of samples and utilizes adsorbent-containing coated devices.
The sample preparation can be performed in a high-throughput environment using standard 96-well plates and robotic equipment. The results of BioSPME protein binding measurements will be presented for analytes across the range of hydrophobicities, molecular weights, and charges.
Key learning objectives
- Learn about a new high-throughput method for measuring protein binding
- Understand the importance of different steps in the BioSPME method and paths to resolve analytical challenges
- Compare BioSPME to other protein binding methods
Who should attend?
Pharmaceutical laboratory scientists and managers working in drug metabolism and pharmacokinetics (DMPK) and early drug candidates characterization, analytical chemists in testing labs and universities, method developers, and early adopters of innovative technology.
Presenter: Dr. Olga Shimelis (R&D manager, Sample Preparation, Merck KGaA)
Dr. Olga Shimelis worked for MilliporeSigma in multiple R&D roles at the Bellefonte (PA, USA) site, primarily working on the development of sample preparation products for chromatographic separations. Prior to this, Shimelis was a research scientist at Northeastern University (Boston, MA) with focus on DNA extraction and identification and analysis of DNA adducts. Olga holds a Ph.D. in Analytical Chemistry from the University of Oklahoma, USA.
Moderator: Charlie Carter (Editorial Team, SelectScience)
Charlie studied neuroscience at the University of Bristol, UK, before completing a Masters in Science Communication. As a member of the Editorial team, Charlie plays an integral role in shaping the content on SelectScience.
