Waters LC Symposium - Materials and Pharma

From the everyday consumer to scientists in the laboratory, we all rely on accurate information to make critical decisions.

Waters Corporation is pleased to bring together chromatography thought leaders for a week of scientific talks, live demonstrations, panel discussions, and networking regarding novel liquid chromatography technologies and applications.

Join us for this virtual symposium beginning with a plenary session on Monday, March 22nd and followed by application sessions for Pharma, Food, Materials and Biomedical Research throughout the week!

THURSDAY, MARCH 25, 2021

Morning Session - 5:00 - 6:30pm CET

Accelerating Materials Innovation with Modern Separations Technologies

Intense pressures from consumers and regulatory bodies for safer, more sustainable, and higher-performing materials require precise analytical and measurement tools that help secure a first-to-market advantage and adhere to critical regulations by providing deep insights into polymer specimen quickly, efficiently, and with a high degree of reliability. This session will provide a series of talks on polymer separation techniques and capabilities.

Presentations:

1. Welcome/Introduction (Bryan Katzenmeyer, Ph.D., Waters Corporation)

Presenter: Bryan Katzenmeyer, Ph.D. (Senior Manager, Materials Science, Waters Corporation)

Bryan Katzenmeyer has over 10+ years of experience specializing in mass spectrometry and separation techniques for the characterization of materials, polymers, monomers, and small molecules as well as increasing leadership roles within technical organizations. He currently oversees the Americas Materials Science business marketing segment for Waters Corporation. The Materials Science business market focuses on polymers, fine and specialty chemicals, extractables/leachables, medical device testing, cosmetics and personal care products, fuel/energy, and agrochemicals. Prior to joining Waters, Bryan was an Analytical Group Leader and Senior Scientist at Valspar (now part of Sherwin-Williams). While here he managed the liquid chromatography and mass spectrometry team focused on developing and validating analytical methodologies to characterize extractables and leachables, resins, oligomers, monomers, and other small molecules in packaging coatings for the food and beverage industries. Bryan received his Ph.D. in Polymer-Analytical Chemistry at The University of Akron working under Distinguished Professor Chrys Wesdemiotis. Here, he researched interfacing liquid chromatography and ion mobility separation with multi-dimensional mass spectrometry for the structural characterization of polymeric materials. He also obtained a M.S. in Chemistry from the University of Wisconsin-Madison and a B.S. in Chemistry from Penn State University.

2. Multi-Detector Size Exclusion Chromatography: Accelerating Innovation Through Greater Insight Into Polmer Performance Properties

Presenter: Amandaa Brewer, Ph.D. (Senior Research Scientist, Arkema)

Amandaa K. Brewer received her Ph.D. in Analytical Chemistry in 2010 from Florida State University (FSU) and her B.S. in Chemistry from Roanoke College in 2005. Her Ph.D. thesis was under Andre Striegel and titled “Multi-Detector Hydrodynamic Chromatography: Particle Characterization and Ultra-High Molar Mass Polymer Analysis.” From 2011 to 2015 she worked at Tosoh Bioscience LLC, where she was first the GPC Technical Specialist and later advanced to the GPC Sales Support Leader. In May 2015 Amandaa joined Arkema Inc., at their North America Research and Development site in King of Prussia, Pennsylvania. She is currently a Senior Research Scientist in the Analytical and Systems Research Group at Arkema and heads the Gel Permeation Chromatography Laboratory. Her research interests are in the area of macromolecular characterization, in particular in using structure-property relationships obtained by multi-detector size-based separations techniques to aid in the understanding of end-product performance and applications as well as the characterization of ultra-high molar mass polymers and applying multi-detector hydrodynamic chromatography to industrial applications. Amandaa is the author of peer-reviewed publications focusing in the area of size based separation methods such as size-exclusion and hydrodynamic chromatography coupled to multi detection methods, namely multi-angle light scattering, quasi-elastic light scattering, differential viscometry, and differential refractometry. She has also published an encyclopedia article on gel-permeation column packing material and lectured in the area of multi-detector size-exclusion chromatography.

3. Expanding Detection Capabilities in SEC and APC: On-line SEC-ICP/MS and APC-ICP/MS Hyphenation

Presenter: Miroslav Janco, Ph.D. (Senior Research Scientist, Dow)

Dr. Miroslav Janco is a senior research scientist and a Polymer Separations GTN leader within the Analytical Science team of the Core R&D organization at Dow Chemical. He holds a M.S. with honors in Chemical Engineering from the Institute of Fine Chemical Technology in Moscow, Russia and a Ph.D. in Macromolecular Chemistry from the Polymer Institute of the Slovak Academy of Sciences in Bratislava. His extensive career in the field of separation science and analytical chemistry was built in renowned laboratories around the word including Osaka University (Japan), University of California—Berkeley, Hahn-Meitner Institute (Berlin, Germany), and the University of Torino (Italy) where he developed a unique LC CAP-NMR hyphenated technique for the separation of polymers by tacticity, fast polymer separations by HPLC on monolithic columns and applied LC CAP for separations of block copolymers, respectively. Currently, his research is focused on the separation and characterization of polymers on both particle and molecular levels by HDC and LC, including SEC, HPLC, LC CAP modes using conventional (RI, UV, ELSD) and enhanced (LS, VIS, ICP/MS, MALDI and NMR) detections as well as coupled (2D-LC) and hyphenated (LC-ICP/MS and LC-NMR) techniques. Dr. Janco has authored or coauthored 26 original scientific papers in peer-reviewed journals and presented his research at more than 60 international conferences. His latest contribution to the field of polymer separation and characterization is development of Ultra-High Pressure Size Exclusion Chromatography (UHP SEC) commercialized as Advanced Polymer Chromatography (APC) by Waters.

4. Recycling Gradients in Polymer Chromatography, A New Approach in HPLC on Polymers? (Bastiaan Staal, Ph.D., BASF)

Presenter: Bastiaan Staal, Ph.D. (Head of Laboratory, BASF)

Dr. Bastiaan Staal is a polymer chemist who finished his Ph.D. in 2005 in the University of Eindhoven (the Netherlands) on copolymer characterization by MALDI-TOF-MS. Since 2006 he is a lab leader at BASF, responsible for GPC and HPLC of polymers for the central research at BASF. His main interests include developing alternative methods in data processing for both HPLC and GPC (mainly handling nonlinear detectors), searching for stable conditions for performing proper GPC, unraveling (MALDI) MS data of co-polymers and hyphenation techniques like GPC-IR, and pushing 2D chromatography (HPLCxGPC) to its limits. His main drive is forming the bridge between theory and the industrial praxis.

Afternoon Session - 7:30 - 9:00pm CET

LC Method Migration - Will my Validated Method Work on this New LC Sytem?

Concerned about your validated LC method working on the new instrument? Excited about getting even more out of your method with newer LC systems? This session will introduce a process to identify and mitigate risk due to instrument performance when switching methods to upgraded or new instruments. The session will also address how to scale LC methods.

Presentations:

1. Mitigating Risk While Upgrading LC Assets in the Regulated Laboratory using Quality by Design

Presenter: Pauline McGregor, Ph.D. (CChem MRSC, PMcG Consulting)

Pauline McGregor Ph.D. CChem MRSC founded PMcG Consulting in September 2006. She has over thirty years’ experience in the Pharmaceutical industry and holds a PhD in organic, analytical chemistry . She originally came to Canada from Edinburgh, Scotland in 1995 to carry out her postdoctoral studies at the University of Western Ontario. Pauline brings a technical expertise to laboratories which enable her to assist them to develop, transfer, verify and validate analytical procedures, and also optimize efficiency with regards to laboratory operations and troubleshooting in an analytical development and QC environment. She been involved in the development and evolution of lifecycle management for analytical procedures and AQbD since 2010. Pauline was a member of the USP expert panel for Validation, Verification and Transfer of Analytical Procedures and a member of a USP Chemical Medicines expert review committee. She continues to be a USP volunteer Expert Advisor and is a Member of the Royal Society of Chemistry , UK.

2. Instrument Suitability Evaluation of HPLC Systems for a USP Organic Impurities (Paula Hong, Ph.D., Waters Corporation)

Presenter: Paula Hong, Ph.D. (Principal Consulting Scientist, Waters Corporation)

Paula Hong is a Principal Consulting Scientist at Waters Corporation in the Systems Design and Development Application Laboratory. She received her Ph.D. in Inorganic Chemistry from The University of Pennsylvania (Philadelphia, PA), focusing on the reactivity of transition metal/silane complexes. Paula has over 15 years’ experience in the area of LC and LC/MS applications, including amino acid analysis, ion-exchange and peptide mapping. She began her career at Waters in the chemistry division focusing on novel column chemistries for biopharmaceutical applications, including studies on the first hybrid sub 2-µm SEC column. Her more recent work has focused on understanding the role of instrumentation characteristics on chromatographic separations. These studies have included method development for both reversed-phase and supercritical fluid applications as well as method transfer. She has authored over 25 journal articles, white papers, and application notes on a variety of chromatographic principles.

3. Migration of Chromatographic Procedures (Oscar Quattrocchi, D’Amico Sistemas and US Pharmacopeia)

Presenter: Oscar Quattrocchi (Training Manager, D’Amico Sistemas and US Pharmacopeia)

Oscar Quattrocchi is currently Training Manager at D´Amico Sistemas S.A. since 2008 and a member of the USP General Chapters Expert Committee, Chemical Analysis since 2005, now in the fourth cycle finishing in 2025, former Vicechair of the USP GCEC, former Chair of the USP Residual Solvents Expert Panel, former Vicechair of the USP Medicines Compendium and currently Chair of the USP Spanish Translation Expert Panel. He had worked more than 30 years in the Pharmaceutical Industry as Manager for Analytical Development, Stability Testing and international registration of Drug Substances and Drug Products. He published two books on HPLC and several articles in scientific publications and was a speaker in numerous congresses and symposiums in Argentina, Brazil, and the USA.

4. Panel Discussion (Moderated by: Isabelle VuTrieu, Adriana Tirado, Waters Corporation)

Moderated by: Adriana Tirado (Market Development Specialist, Mexico & LAD, Waters Corporation)

Adriana is the Market Development Specialist in the Spanish-speaking countries of Latin America at Waters and has 15 years of experience in Sales & business development. She joined Waters in 2012 as a sales representative for northern Mexico. She has worked in different companies as a sales executive developing brand presence in the analytical & Life Sciences markets, where she also held the position of service engineer and technical support engineer in liquid chromatography. Prior to that, she was an Associate professor in the Autonomous University of Nuevo León working in the analytical area and supporting the natural products research line of the analytical department in the Faculty of Medicine. She studied Clinical Chemistry Biologist and has a master’s degree in Biomedical Chemistry from the Autonomous University of Nuevo León.