Automated Sample Preparation to Overcome Key Challenges in the Analysis of Nitrosamines in Drug Substance and Drug Product
This webinar will discuss the optimization and validation of a fully automated solution for the sample preparation and LC-MS/MS analysis of six target nitrosamines in two classes of drug substance, Irbesartan (angiotensin II receptor antagonist) and Metformin (biguanide analogue antidiabetic). The method involves vigorous mixing, sonication, centrifugation and filtration. All modules are fully automated.
It will demonstrate how the inherent benefits of automated sample preparation are not only valuable from a health, safety, and time perspective, but can be extremely beneficial in controlling and containing sources of contamination when instrumental sensitivity and selectivity matters the most.
Key Learning Objectives
- Benefits of a fully automated solution to tackle the extremely complex analytical challenge of nitrosamines impurities in medicine products:
- Analytical figures of merit
- Mitigated contamination risks
- Reduced environmental exposure
- High throughput unattended operation
Who Should Attend
- Laboratory managers
- Chromatographers
- Analytical chemists and scientists
- New product developers
- Pharma manufacturing and quality control managers
Presenter: Camilla Liscio (Senior Application Chemist, Anatune Ltd)
Presenter: Catherine Dold (Health & Environment Writer, C&EN Media Group)
