Recent Developments in Ion Mobility - Mass Spectrometry: Enabling Structural and Isomeric Separation for Large and Small Molecules

The talk will present on two specific areas of developments in Ion Mobility - Mass Spectrometry. The first topic is on the development and application of Collision Induced Activation and Unfolding as applied to uncovering structural differences in native proteins. The second topic focuses on the achievements in high resolution ion mobility analysis including Structures for Lossless Ion Manipulation (SLIM) and the use of multiplexed data acquisition and post-acquisition maximum likelihood deconvolution enabled Hadamard transform demultiplexing (HRdm) and its application to biologically relevant small molecules.

For Research Use Only. Not for use in diagnostic procedures.

Presenter: John Fjeldsted, PhD (Senior Director for Intellectual Property & Ion Mobility, Agilent Technologies, Inc.)

John’s work in mass spectrometry began in the early 1980’s at Brigham Young Univ. where he received his Ph.D. under Prof. Milton Lee. He joined HP/Agilent in 1984 and has held many many technical and management R&D positions. John lead the instrument development teams for Agilent’s launch of triple quad and quadrupole time-of-flight mass spectrometers in 2006 followed by subsequent product releases. From 2009 - 2012 John served as GM and then Agilent VP of the LC/MS business. Since 2014 John has lead Agilent’s ion mobility program and mass spec intellectual property. In 2018 he was honored by receiving the title of Agilent Distinguished Scientist. In his spare time, he enjoys photography, waterskiing and spending time with his dear wife, their 4 children and 13 grandchildren.