Polishing Strategies for Full Adeno-Associated Capsid Enrichment
As adeno-associated virus (AAV) therapies advance toward larger-scale manufacturing, achieving consistent full capsid enrichment remains a critical challenge. Variability between serotypes and purification conditions can affect product quality, recovery, and process scalability.
In this webinar, Chiu Lau-Barre will share practical strategies for developing robust anion exchange (AEX) polishing workflows, drawing on real-world AAV2 and AAV9 examples.
Attendees will gain insight into approaches for improving purification performance, streamlining process development, and supporting efficient scale-up. The session will also highlight how modern screening tools can help accelerate decision-making and reduce development timelines.
Attend this webinar to:
- Understand key variables that influence AEX polishing performance of full/empty capsid separation for AAVs
- Explore AAV2 and AAV9 case studies demonstrating how AEX polishing methods can be optimized across serotypes
- Learn how high-throughput AEX screening can accelerate process development and support scalable workflow implementation
- Identify process development strategies that can help reduce optimization timelines and support scale-up readiness
Presenter: Chiu Lau-Barre (Staff Scientist, Field Applications at Thermo Fisher Scientific)
Chiu Lau-Barre is a staff scientist at Thermo Fisher Scientific, where she supports customers in purification process development and troubleshooting across a range of biomolecules, including antibodies and adeno-associated viral (AAV) vectors. With more than 15 years of biopharmaceutical industry experience, she has held scientific leadership roles at Pfizer and Eli Lilly, contributing to antibody and protein therapeutic development from early-stage screening through process development. Her expertise spans purification strategy, developability assessment and scalable bioprocess workflows. Chiu holds a bachelor's degree in Biochemistry from the University of California, Santa Barbara.
