Purifying Problematic Compounds by RP-LC: Simplified Workflows for Better Outcomes with Inert Preparative Columns

Simplified Prep LC Workflows for Higher Purity and Recovery

In discovery chemistry, synthesizing novel compounds to achieve the greatest purity and recovery is non-negotiable. Efficient analysis and isolation require effective LC strategies to achieve the best outcomes.

In this webinar, we will address scaling separations of problematic compounds that are prone to interact with metal surfaces (aka ‘Sticky Targets’).

Whether tackling prep-scale isolation of high-value, molecular targets from a complex matrix or scaling up operations to optimize purity and recovery of diverse sets of molecular entities, inert preparative columns can help achieve exceptional isolation outcomes to achieve exceptional isolation outcomes.

Why you should attend

Learn how Waters MaxPeak™ Premier OBD Prep Columns, enabled with HPS (High-Performance Surface) Technology, allows chemists to achieve up to 3x increased peak responses for improved target purities while reducing column pre-conditioning and fraction dry-down times.

• Achieve predictable scale-up from Waters MaxPeak Premier analytical columns
• Optimize fractionation with greater peak responses and better peak shapes
• Improve target recoveries (especially for impurities or compounds present in minute amounts) 
• Increase high-value target purity (compared to use of traditional stainless-steel RP columns)
• Reduce fraction volumes and dry-down times
• Increase productivity by avoiding column pre-conditioning

Who should attend

This webinar is designed for you if you are working in:

•  Discovery Synthesis laboratories in pharma, academia, ag chem, natural product and other research environments purifying final targets for subsequent synthetic transformation or testing.
•  Chemical Development scale-up laboratories doing impurity isolation and molecular scale-up.

Speaker: Jo-Ann Jablonski (Principal Scientist, Waters Corporation)

Jo-Ann Jablonski is a Principal Scientist in the Core Separations Portfolio group at Waters Corporation.

Prior to joining Waters, she worked in biotechnology synthesizing, characterizing, and purifying biomolecules for research and development. She later transitioned to developing a process for the manufacture of a therapeutic peptide product.

Since joining Waters, Jo-Ann has provided technical support, training, and application assistance to customers using Waters’ chemistry products and instrumentation, with an emphasis on purification technologies.