Addressing Common Misconceptions in Residual Host Cell DNA Testing
Residual host cell DNA testing is a critical component of biotherapeutic quality control (QC), particularly as products advance through purification and into final dosage form.
This webinar explores common misconceptions that can impact the accuracy, robustness, and regulatory compliance of residual DNA testing strategies. It reviews global regulatory expectations and outlines key criteria for selecting fit-for-purpose DNA quantitation methods.
Emphasis is placed on the importance of effective sample preparation for measuring ultra-low DNA levels in complex matrices, as well as practical approaches for implementing reliable, validated workflows—from development through to routine QC—ensuring consistent, audit-ready performance.
Attend this webinar to:
- Explore the analytical challenges of residual DNA quantitation in purified bioprocess samples
- Identify key technical criteria for selecting a fit-for-purpose residual DNA quantitation methods
- Recognize the role of integrated workflows in achieving consistent, reproducible, and compliant residual DNA measurements
- Understand the impact of sample preparation, DNA standards, and fragment size on quantitation accuracy
Presenter: Ilaria Scarfone, PhD (Senior Field Application Scientist, Thermo Fisher Scientific)
Dr. Ilaria Scarfone is a field application specialist in Thermo Fisher Scientific's pharma analytics team, a role she has held since September 2019. She currently lives in Pisa and supports clients in South West Europe. Ilaria completed her PhD in industrial biotechnology at the University of Milan in collaboration with the Cell Biology Research Center of Montpellier and subsequently spent two years as a postdoctoral researcher at the Grenoble Atomic Energy Commission. In addition to her academic research background, Ilaria earned a master’s in business and administration from the Institut d'Administration des Entreprises in Montpellier in 2018, before joiningThermo Fisher Scientific as a technical specialist for the pharma analytics portfolio.
