SCIEX summit Day one: Shaping the future of analytical science
Join us in October to hear first-hand how scientists and researchers from around the globe are driving innovation through analytical science—as they share insights on the latest trends, advanced workflows, and techniques that are helping to shape the future of food safety, environmental health, pharmaceutical and biopharmaceutical breakthroughs, and cutting-edge techniques in biomedical and omics research.
This year’s summit will spotlight:
- Future-focused solutions: Explore how next-generation technologies and approaches are redefining the boundaries of analytical capability.
- Advanced strategies: Dive into cutting-edge methodologies that are transforming laboratories across pharma, biotech, environmental, food, and clinical domains.
- Emerging trends: Gain foresight into trends driving the future of analytical science
Whether you're a scientist, researcher, or industry innovator, this is your moment to be part of the conversations. Secure your spot today and be among the first to access exclusive content, speaker announcements, and agenda previews. Be ready for what’s next in analytical excellence.
Day one: Shaping the future of analytical science
- Be inspired by the technologies and analytical approaches that are redefining the future of analytical science—enabling data-driven decisions, faster breakthroughs, and greater impact.
- Discover how automation and software can accelerate bioanalysis in a CRO environment.
- Confirmed speakers include: Washington University, Dash Bio, The Buck Institute, and AstraZeneca.
Agenda-at-a-glance
Welcome and introduction to shaping the future of analytical science
- Jamie Wighton (Senior Director, LCMS Research, SCIEX)
Back to the future with sliding MS2 windows on the ZenoTOF 8600 system
- Gary Patti (Professor of Chemistry and of Genetics and Medicine (School of Medicine), Washington University, St Louis)
Mass spectrometry-based metabolomics aims to profile the comprehensive collection of small molecules from a biological system. A typical experiment generally measures more signals than can be targeted by conventional data-dependent MS2 analysis. Innovative strategies to improve MS2 coverage and deconvolute the chimeric spectra are needed.
Key takeaways from the presentation:
- Overview of motivation for sliding MS2 windows in metabolomics
- Example of metabolomics data from the ZenoTOF 8600 system
- Analysis of improved coverage and data quality
Accelerating bioanalysis with automation and software: a next-generation CRO platform
- Dmitri Konorev, Ph.D. (Senior Scientist)
Drug development remains a key bottleneck despite rapid advances in drug discovery. To address this, Dash is building a fully automated robotics platform to streamline bioanalytical method development, sample preparation, and analysis, from early discovery to clinical samples.
Key takeaways from the presentation:
- For LC/MS assays, the platform is integrated with a SCIEX 7500+ system.
- Case studies across multiple modalities demonstrate robust quantitative performance and high throughput across diverse assay formats, resulting in rapid turn around times of days, not months
Proteomic tools (SWATH DIA and ZT Scan) to investigate skeletal health in the context of aging and cancer
- Birgit Schilling, PhD (Professor, The Buck Institute)
We are using the ZenoTOF 7600+ system to investigate human breast cancer subtypes, specifically metaplastic breast cancer, which is particularly detrimental. We also investigate metastatic cancer to the bone (40% of all metastasis sites of breast cancer).
Key takeaways from the presentation:
- Precise quantification using SWATH DIA and ZT Scan DIA
- Data can be further mined post-acquisition.
- High throughput
Advancement of capillary gel electrophoresis through the use of native fluorescence detection
- Jessica Taylor (Senior Research Associate, Teva Pharmaceuticals)
Peak integration in protein capillary gel electrophoresis (CGE) is notoriously difficult due to the noisy, wavy baselines that can occur using standard UV methods. Native fluorescence detection (NFD) utilizes the intrinsic fluorescence capabilities of antibodies from their tryptophan, tyrosine, and phenylalanine residues. Teva evaluated NFD on the BioPhase 8800 system to determine how the baselines, reproducibility, and sensitivity of the assay compared to methods using traditional UV detection, while also ensuring that all minor peaks are detectable using both detection mechanisms. The data gathered at Teva shows that NFD led to notable improvements in the baseline, making automatic integration possible, increased assay sensitivity, while also maintaining comparable reported data and reproducibility to UV methods. Thus far, the improvements in detection from using NFD provide significant time savings in data processing, which makes the integration process more GMP and QC friendly.
Key takeaways from the presentation:
- How native fluorescence detection enables easier peak integration compared to standard UV methods.
- What an increase in assay sensitivity means for CE-SDS
- How improvements streamline data processing and saves time in analytical workflows.
Real stories from scientists: unlocking efficiency, confidence, and control with SCIEX OS software
- Jessica Steed (Global Marketing Specialist, SCIEX)
Q&A roundtable: shaping the future of analytical science
- Moderated by: Jamie Wighton
- Jamie joined SCIEX 20 years ago and has held multiple technical and leadership roles throughout his career at SCIEX. Starting out as an engineer in manufacturing operations, Jamie has since led teams in supply chain, product development, and most recently the research and product applications teams within R&D. Prior to joining SCIEX, Jamie worked at JDS Uniphase as an optical test engineer.
