Waters 2025 LC Symposium - Day 1 - Addressing Analytical Challenges in Advanced Therapeutics
Waters 2025 LC Symposium
Waters 2025 LC Symposium – LC Solutions for Emerging Therapeutics
Overview
Liquid chromatography plays a critical role in ensuring the safety of emerging therapeutics such as PROTACs, cell and gene therapies, and GLP-1 drug products. Join this free symposium to gain insights from forward-thinking global leaders in LC technology. You will learn about the latest advancements addressing analytical and purification challenges posed by these transformative therapeutics.
Learning objectives
- Learn how our experts are handling unique analytical challenges in emerging therapeutics
- Explore advanced LC technologies applied to critical issues in PROTACs, cell and gene therapies, and GLP-1 drugs
- Pose your questions to our expert panel on your analytical challenges with emerging therapeutics
Who should attend
- LC scientists, managers and directors from the pharmaceutical industry
Day 1: Addressing Analytical Challenges in Advanced Therapeutics
The rapid expansion of emerging therapeutics—such as RNA-based drugs and gene therapies—has introduced unprecedented complexity into pharmaceutical analysis. Our panel of experts will explore how advanced LC techniques are being adapted to meet the demands of modern drug modalities. Topics include the use of alternative approaches such as size exclusion chromatography (SEC) with ultra-wide pore columns and the (re)emerging technique of Slalom Chromatography. Attendees will also gain insights into coupling LC with mass spectrometry (MS) and multi-angle light scattering (MALS) for comprehensive characterization of complex biopharmaceuticals.
This session offers practical knowledge and forward-looking perspectives for LC chromatographers looking to expand their analytical toolbox and support the development of next-generation therapeutics.
Presenter: Arnaud Delobel Ph.D. (Director, R&D and Innovation Quality Assistance)
Arnaud Delobel is the R&D and Innovation Director at Quality Assistance, with expertise in analytical sciences spanning across all types of therapeutic modalities. He is a recognized expert in the 'MAB Working Party' at the European Directorate for the Quality of Medicines (EDQM) in Strasbourg. Additionally, he contributes to academic discourse through lectures at the University of Strasbourg.
Arnaud graduated from ECPM Strasbourg, focusing his PhD on the mass spectrometry of proteins and peptides at the CNRS in Gif-sur-Yvette, France. He then completed a post-doctoral fellowship in Liège, Belgium, centered on proteomics. Joining Quality Assistance in 2006, Arnaud has climbed the ranks, holding various roles before assuming his current position as R&D and Innovation Director in 2016.
In his role, Arnaud oversees internal R&D initiatives aimed at implementing cutting-edge analytical technologies. These technologies are designed to be offered by Quality Assistance to its clientele. He also guides Product Experts in identifying market needs, leveraging insights from Management, Regulatory Affairs, external experts, and comprehensive data analytics. His team works diligently to transform these insights into innovative R&D services.
Presenter: Fabrice Gritti, Ph.D. (Consulting Scientist, Waters Corporation)
Fabrice G. Gritti received a Ph.D. in Chemistry and Physics of Condensed Matter from the University of Bordeaux I (France) in 2001. He then worked as a research scientist at the University of Tennessee (Knoxville, TN) from 2002 to 2014 in the research group of the late Prof. Georges Guiochon. He joined Waters Corporation in 2015 where he is currently a consulting scientist.
Dr. Gritti’s main research interests involve liquid/solid adsorption thermodynamics and mass transfer in heterogeneous media used in the field of separation science. During the last 25 years, he has provided fundamental insights in preparative liquid chromatography and on the retention mechanisms in liquid chromatography (LC), refined the detailed theory of band broadening in modern LC columns, and contributed to improve column and instrument technologies in both LC and supercritical fluid chromatography for various relevant applications.
Dr. Gritti has been invited to give about thirty seminars on diverse topics of chromatographic sciences worldwide. He has delivered over a hundred invited keynote lectures and published over three hundred peer-reviewed articles. Dr. Gritti was the recipient of the 2013 Chromatographic Society Jubilee Medal, the 2019 JFK Huber Lecture Award, the 2022 Eastern Analytical Symposium Award for Outstanding Achievements in Separation Science, the 2023 Csaba Horvath Memorial Award for propagation of separation sciences throughout the world and co-operation in the development of chromatography in Hungary, and the 2024 A.J.P. Martin Medal from the UK-based Chromatographic Society.
Presenter: Bala Addepalli, Ph.D. (Director R&D, Waters Corporation)
Dr. Bala Addepalli has an impressive background in the field of cell and gene therapy product analysis. Currently, he is the Director of the Evaluations and Application Science Team under the Genetic Medicine analysis portfolio at Waters Corporation. His work focuses on developing efficient analytical approaches for characterization of DNA, RNA, LNPs(lipid nanoparticles), and viral vectors using liquid chromatography coupled with mass spectrometry or light scattering techniques.
Before joining Waters, Bala made significant contributions at the University of Cincinnati, where he developed novel enzymes and analytical methods for RNA characterization. His earlier work includes research on mRNA polyadenylation at the University of Kentucky, and viral RNA characterization during his graduate studies in India.
With over 60 publications and numerous presentations at scientific meetings, Bala's expertise is well-recognized in the scientific community.
Moderator: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas Waters Corporation)
Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.
