Innovations in protein characterization
Biotherapeutics offer targeted therapies for treating a wide range of diseases with greater specificity and efficacy. However, unlike traditional small-molecule drugs, biotherapeutics are typically larger and more complex, requiring advanced techniques for their production, purification, and characterization.
Therapeutic proteins, first introduced many years ago, have continually advanced in complexity. Since the introduction of monoclonal antibodies, we now have antibody drug conjugates, bispecific antibodies, fragments and fusion proteins, all of which are in various stages of development.
To keep pace with biotherapeutics advances, analytical techniques must also advance.
In this webinar, we will present chromatography findings on:
- New workflows for intact and peptide mapping characterization of proteins
- Advanced column chemistries for charge variant analysis with pH and salt gradients
- Rapid desalting SEC column for high throughput analysis, ADC analysis with HIC and reversed phase chemistries
- New digestion workflows coupled to a new peptide mapping column for sequence verification and post translation modification analysis
This live webinar will be an excellent opportunity to boost your R&D capabilities and strengthen your QC analytical methods for the characterization of biotherapeutics and gene therapies. Dr. Ken Cook will be presenting and answering your questions live.
With over 20 years of innovation, Thermo Fisher Scientific is a leader in biomolecule separation and characterization, supported by a wealth of published research.
Who should attend?
- Pharmaceutical and Biotech Researchers: Researchers involved in the development and characterization of biotherapeutics and gene therapies, including those working with therapeutic proteins.
- Quality Control (QC) Analysts: Analysts responsible for ensuring the quality and consistency of biotherapeutic products, who will benefit from advanced methods in characterization and validation.
- R&D Managers: Managers who oversee research and development teams working with biotherapeutics, looking to enhance their workflows and methodologies.
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Presenter: Dr. Ken Cook (Applications Scientists Manager, Thermo Fisher Scientific)
Moved to industry from a University lectureship in Biochemistry, University of Newcastle upon Tyne, following 7 years’ experience in academia. Now with over 35 years’ experience with Thermo Fisher Scientific using a wide range of analytical equipment and software. Publications range from metabolomics, proteomics to large biopharmaceutical drug analysis. Current job title is the European manager for the BioPharma expert support group. This involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Characterization methods of Bio-therapeutics include, monoclonal antibodies, peptides, AAV analytical development, small and large RNA analysis including sequence mapping of mRNA by LC/HRMS.
