Expanding Capabilities in QC Analyses with Advanced LC Detection
Quality control (QC) labs today require instruments that can accurately and reproducibly tackle a broad range of applications in a way that is reliable and compliance ready.
Join us for an interactive educational session where we explore how the expansion of liquid chromatography (LC) detection can significantly enhance the capabilities and possibilities in QC analyses. See how the addition of PDA detection in an integrated, next-generation HPLC system, elevates QC labs to achieve:
- Enhanced analytical capabilities: Discover how the use of columns with smaller particle sizes facilitates seamless method adjustment or scaling on the Alliance iS HPLC System.
- Wide application range: Suitable for a broad range of compounds due to its versatile wavelength range.
- Method migration support: Tools to support moving methods from other HPLC systems, ensuring comparable results.
- Data integrity: Provides reliable and reproducible results crucial for regulatory compliance and quality control.
Introducing the Alliance iS HPLC System
The Alliance iS HPLC system is the first-of-its-kind LC system that brings intuitive simplicity and performance to routine analyses. Initially impressing pharmaceutical QC lab teams with its integrated TUV detector, it has evolved to serve QC biopharma labs with the Alliance iS Bio HPLC System, featuring MaxPeak High Performance Surfaces (HPS) Technology.
Now, with the latest addition of the integrated PDA detector, the Alliance iS HPLC System enters a whole new arena of applications.
Next-Level UV Analysis for QC Labs
- 3D spectral data acquisition wavelength: Capable of recording multiple 2D channels and 3D spectrum.
- Versatile PDA detector: Applicable to any UV-based HPLC method with an wavelength range of 190-800 nm, allowing for the exploration and tracking of multiple peaks of interest with various lambda max.
- Peak purity analysis: Conduct peak purity analysis through Empower Chromatography Data System (CDS).
- Peak identification and confirmation: Identify or confirm peaks by individual spectrum, a key step in assay, impurity, and ID pharmaceutical methods.
Case Studies
- Scaling a method from the Alliance iS HPLC System with PDA Detector: Learn how to scale an HPLC method to 2.5 um particle column on the Alliance iS HPLC System with PDA detector, taking advantage of pressure range for shorter run times and lower solvent consumption.
- Method migration of a USP monograph to the Alliance iS HPLC System with PDA Detector: Understand impact of instrument characteristics on method migration or transfer, and how to successfully move your method from different vendor systems to the Alliance iS HPLC System with PDA Detector.
Don't miss this opportunity to learn how to leverage the latest advancements in LC detection to enhance your QC lab's capabilities and efficiency.
Presenter: Patrick Flanagan (Principal Product Marketing Manager, QA/QC, Waters Corporation)
Patrick Flanagan is a Principal Product Marketing Manager in Waters’ QA/QC Division, where he has worked for over six years. He currently is responsible for product marketing and product management activities for Waters’ next generation HPLC systems.
He received his bachelor’s in science degree from Worcester Polytechnic Institute in Biochemistry and worked for 15 years as a formulation scientist.
Patrick began his career in Waters’ product management department responsible for optical detection, multi-dimensional systems, the Alliance HPLC System, Arc Premier System, Arc HPLC System, and the new Alliance iS HPLC System. His recent work has been focused on the development of innovative new products for pharmaceutical QA/QC departments.
Presenter: Lise Gauthier (Principal Evaluation Scientist, Waters Corporation)
Lise Gauthier is Principal Scientist within the QA/QC Business Strategy group at Waters Corporation in Milford, MA. Prior to joining Waters in 2014, Lise worked in the pharmaceutical industry holding within Quality Assurance and Drug Discovery. Her current role at Waters includes system validation and evaluation of competitive systems
Presenter: Amanda Dlugasch (Senior Scientist, Waters Corporation)
Amanda Dlugasch is a Senior Scientist in the QA/QC Strategy and Growth Department at Waters Corporation in Milford, MA. She received her B.A. in Chemistry from Manhattanville College and her M.S. in Chemistry from Sacred Heart University. She started at Waters Corporation in the Instrument Evaluation group developing qualification protocols for newly released products. Upon transferring to the QA/QC Strategy and Growth Department, her initial focus was to evaluate and provide application and training material for the release of ACQUITY Arc UHPLC System. She studied how LC instrument design and LC system characteristics influence chromatography when transferring, scaling, and modernizing methods. Currently, she is working on evaluating the Alliance iS HPLC System.
