Enhancing MS-Based Omics Analysis in a Model Organism
Mass spectrometry (MS)-based omics technologies have revolutionized our understanding of molecular changes in organisms and are crucial for studying metabolism and related diseases through lipidomics and metabolomics.
Despite significant advances, there is still a need for robust analytical methodologies in data acquisition, data processing and annotation.
This webinar will demonstrate how LC-Zeno SWATH DIA outperforms conventional DDA in annotating metabolites and lipids in the model organism Gammarus fossarum. Additionally, the presentation will showcase the effectiveness of electron activated dissociation (EAD) in characterizing lipid species and elucidating metabolite isomers. Finally, the webinar will illustrate how EAD and high-resolution targeted approaches improve structural elucidation and molecular network construction.
Attend this webinar to:
Learn about the benefits of LC-Zeno SWATH DIA over conventional DDA methods for metabolite and lipid annotation
Explore the implementation of EAD for enhanced lipid species characterization and metabolite isomer elucidation
Understand how EAD improves structural elucidation and molecular network construction
Presenter: Dr. Valentina Calabrese (Postdoctoral Researcher at Institute of Analytical Sciences)
Valentina Calabrese received her Ph.D. in Analytical and Bioanalytical Sciences at University of Palermo, Italy and is currently a postdoctoral researcher at the Institute of Analytical Sciences in Lyon, France. During her career, she specialized in high resolution, ultra-high resolution, and ion mobility mass spectrometry for application on fundamental topics and -omics research, such as metabolomics and lipidomics. Her research activity focuses on new method development and unknown compound annotation through high-resolution mass spectrometry and molecular networking in biological complex samples. She is currently involved in the study of sentinel freshwater organisms, as Gammarus fossarum and works on DDA and SWATH DIA methods with CID or EAD fragmentation strategies along with molecular networking construction for improving structural characterization of small molecules.
