Evosep One in the Clinical Biochemistry Lab

Clinical biochemistry laboratories worldwide measure millions of samples daily from various body fluids such as blood and urine. A growing part of these analyses are performed with LC-MS/MS and especially for diagnostic niches of laboratory medicine, where superior analytical specificity is superior to immunoassays.

Why, how and when ms-based proteomics in laboratory medicine

Millions of samples are being analyzed every day to diagnose, monitor and prognose patients. In most hospitalts this is performed by a department of laboratory medicine using enzyme linked assays, radioimmunoassays and even gel-electrophoreses. More than 50% of every analyses orded at a hospital or at your own general practioneers is a protein. Currently, single assays are used to profile our patients and for decision making.

MS-based proteomics is not used in laboratory medicine for routine diagnostics. In this talk I will discuss how we have been exploring MS-based proteomics for clinical diagnostics for both common and rare diseases and finally I am eager to share our visions on how we believe MS-based proteomics may provide faster and better patient care.

Presenter: Nicolai Wewer Albrecthsen (Associate Professor at Clinical Proteomics and Metabolism, NNF Center for Protein Research, University of Copenhagen, Denmark)

Targeted Proteomics in Biomarker Development and Clinical Diagnostics

Mass spectrometry-based targeted proteomics workflows have within the last decade developed immensely in terms of automation, throughput and robustness – a prerequisite for implementation in the routine clinical biochemistry lab.

In this webinar, I will share my views on the challenges remaining ahead for implementing targeted protein assays as clinical lab tests, and provide examples of applications of MRM-based assays in arterial disease pathophysiology, diabetes and cancer follow-up diagnostics focusing on either multiplexing, high sensitivity or high specificity analysis.

Presenter: Martin Overgaard (Biochemist, Associate Professor, PhD, Department of Clinical Biochemistry Odense University Hospital, Odense, Denmark and Department of Clinical Research, SDU, University of Southern Denmark, Odense, Denmark)