Proteome analysis reveals pathways of corticoid- & shape constraint-induced transdifferentiation of the hepatic cell line HepaRG

HepaRG cells are the most appropriate and versatile cell system surrogate for primary human hepatocytes1. They exhibit unique properties: self-renewal of progenitor cells, full differentiation toward hepatocytes or cholangiocytes, and an ability for retro-differentiation toward a proliferative state.

To unravel the molecular mechanisms controlling such plasticity and HepaRG transdifferentiation abilities, the proteomes of several cell lines derived from HepaRG progenitors were compared.

Presenter: Charlotte Brun (Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, France)