The combination of MALDI-2 and timsTOF fleX brings targeted drug imaging to the next level
Aplikace | 2020 | BrukerInstrumentace
MALDI, MS Imaging, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
ZaměřeníFarmaceutická analýza
VýrobceBruker
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Bruker timsTOF fleX - MALDI Guided SpatialOMx
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Tracking free-toxin distribution in xenografts after in-vivo ADC dosing by MALDI Imaging MALDI-MRMS imaging of free released toxin in xenografts after ADC in-vivo dosing. Abstract Antibody-drug conjugates (ADC), a fast-growing class of anticancer drugs, typically comprise a cytotoxic payload that…
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TIMS enabled quantification of small molecules in MALDI Imaging
2020|Bruker|Technické články
TIMS enabled quantification of small molecules in MALDI Imaging timsTOF fleX was used to demonstrate quantitative mass spectrometry imaging on several drug compounds. Abstract timsTOF fleX was able to separate near-isobaric ions by their ion mobilities, significantly improving targeted compound…
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Rapid pharmacokinetic analysis of small drugs by mass spectrometry imaging combined with product ion analysis
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