Antibody Drug Conjugate (ADC) Load Characterization and Analysis Using the BioAccord and Nano DSC Systems
Aplikace | 2020 | WatersInstrumentace
LC/TOF, LC/HRMS, LC/MS
ZaměřeníKlinická analýza
VýrobceWaters
Klíčová slovadsc, drug, antibody, adcs, bioaccord, conjugate, hydrophobic, conjugates, biochemical, adc, nano, payload, biophysical, brief, dar, molecule, positional, physicochemical, characterization, reexamined, colette, perturbs, disciplinary, quinn, shion, assessment, technology, thermograms, interaction, enthalpy, calorimetry, collected, henry, discoveries, consistent, tells, cytotoxic, system, occupational, conjugation, class, waters, comparability, pharmacokinetics, hic, paired, conjugated, population, consist, biopharmaceuticals
Podobná PDF
Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System
2019|Waters|Technické články
[ TECHNOLOGY BRIEF ] Analysis of Antibody Drug Conjugates (ADCs) by Native Mass Spectrometry on the BioAccord System Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA Drug-to-Antibody Ratio (DAR) determination of Lys and Cys conjugated…
Klíčová slova
bioaccord, bioaccordconjugated, conjugatedadc, adcdar, daradcs, adcsnative, nativedrug, drugsystem, systemantibody, antibodycovalent, covalentsec, secbrief, briefconjugates, conjugatescysteine, cysteinelysine
Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization
2018|Waters|Aplikace
[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…
Klíčová slova
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicconjugated, conjugatedscale, scaleconjugates, conjugatescharacterization, characterizationprotein, proteinuplc, uplcvion, vionconjugation
Analysis of Cysteine-Linked Antibody Drug Conjugates
2017|Agilent Technologies|Aplikace
Analysis of Cysteine-Linked Antibody Drug Conjugates Using Hydrophobic Interaction Chromatography on the Agilent 1260 Infinity II Bio-inert LC Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Hydrophobic interaction chromatography (HIC) is frequently used for the Agilent Technologies, Inc. determination…
Klíčová slova
brentuximab, brentuximabvedotin, vedotindar, darhic, hicdrug, drugantibody, antibodyhydrophobic, hydrophobicmmae, mmaeadcs, adcsadc, adctige, tigeinteraction, interactionmab, mablinked, linkedcysteine
Automating the Determination of Drug-to-Antibody Ratio (DAR) of Antibody Drug Conjugates (ADCs) Based on Separation by Hydrophobic Interaction Chromatography (HIC)
2014|Waters|Aplikace
Automating the Determination of Drug-to-Antibody Ratio (DAR) of Antibody Drug Conjugates (ADCs) Based on Separation by Hydrophobic Interaction Chromatography (HIC) Robert Birdsall, Eoin Cosgrave, Henry Shion, and Weibin Chen Waters Corporation, Milford, MA, USA A P P L I C…
Klíčová slova
dar, darantibody, antibodyadcs, adcsdrug, drugconjugates, conjugatesautomating, automatingcalculations, calculationsratio, ratiocqas, cqasuplc, uplcacquity, acquityhic, hicdetermination, determinationconjugated, conjugatedcysteine
